{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T20:58:22Z","timestamp":1778273902929,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1994,12,15]],"date-time":"1994-12-15T00:00:00Z","timestamp":787449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1994,12,15]]},"abstract":"<jats:p>1. Chloralose\u2010urethane\u2010anaesthetized Wistar rats and stroke\u2010prone spontaneously hypertensive rats (SHRSP) were prepared for measuring renal function. 2. Bilateral brachial nerve stimulation for 15 min, at 1.3 Hz (15 V, 0.2 ms), increased blood pressure from 119 +\/\u2010 2 to 151 +\/\u2010 6 mmHg (P &lt; 0.01) in Wistar rats and from 181 +\/\u2010 6 to 203 +\/\u2010 6 mmHg (P &lt; 0.05) in SHRSP; renal perfusion pressure was mechanically regulated at prestimulus levels but renal blood flow (4.1 +\/\u2010 0.7 ml min\u20101 g\u20101 in Wistar rats and 3.4 +\/\u2010 0.3 ml min\u20101 g\u20101 in SHRSP) and glomerular filtration rate (1.18 +\/\u2010 0.09 ml min\u20101 g\u20101 in Wistar rats and 0.88 +\/\u2010 0.01 ml min\u20101 g\u20101 in SHRSP) decreased between 5 and 30% (P &lt; 0.05\u20100.001). 3. During brachial nerve stimulation, urine flow (13.8 +\/\u2010 2.2 microliters min\u20101 g\u20101) and absolute and fractional sodium excretion (3.70 +\/\u2010 0.64 mumol min\u20101 g\u20101 and 2.06 +\/\u2010 0.23%) decreased by 60\u201070% in the Wistar rats (P &lt; 0.01\u20100.001) and the responses were unaffected by vagotomy or carotid sinus denervation. In the SHRSP, urine flow rate (9.74 +\/\u2010 2.52 microliters min\u20101 g\u20101) and absolute and fractional sodium excretion (1.98 +\/\u2010 0.59 mumol min\u20101 g\u20101 and 1.41 +\/\u2010 0.28%) decreased by 15\u201030% (P &lt; 0.05\u20100.01), decreases which were significantly (P &lt; 0.05) smaller than those observed in the Wistar rats. Moreover, the responses were some 40\u201060% larger in the vagotomized and carotid sinus\u2010denervated SHRSP. 4. The influence of vagal and carotid sinus afferent nerves on the somatosensory\u2010induced renal responses in the Wistar rats was small, whereas in the SHRSP they appeared to exert a marked tonic inhibitory effect. It is concluded that there is excessive baroreceptor restraint on neural regulation of renal function in the SHRSP.<\/jats:p>","DOI":"10.1113\/jphysiol.1994.sp020479","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T11:36:16Z","timestamp":1418816176000},"page":"753-759","source":"Crossref","is-referenced-by-count":16,"title":["Somatosensory regulation of renal function in the stroke\u2010prone spontaneously hypertensive rat."],"prefix":"10.1113","volume":"481","author":[{"given":"G","family":"Davis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E J","family":"Johns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1994,12,15]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1994.sp020479","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1994.sp020479","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T07:17:10Z","timestamp":1698131830000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1994.sp020479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12,15]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,12,15]]}},"alternative-id":["10.1113\/jphysiol.1994.sp020479"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1994.sp020479","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,12,15]]}}}