{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:39:06Z","timestamp":1773308346669,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1995,1,15]],"date-time":"1995-01-15T00:00:00Z","timestamp":790128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1995,1,15]]},"abstract":"<jats:p>1. The effects were studied of the central neurone P\u2010type Ca2+ channel blockers, omega\u2010agatoxin IVA, omega\u2010conotoxin MVIIC (polypeptide toxins) and synthetic funnel\u2010web spider polyamine toxin on acetylcholine release from mouse motor nerve. 2. omega\u2010Agatoxin IVA decreased the quantal content of endplate potentials and blocked synaptic transmission in the nanomolar range in a reversible manner, whereas the other toxins depressed transmission in the hundred micromolar range. 3. The polyamine toxin, but not the polypeptide toxins, decreased the amplitude of the miniature endplate potential. The increase in the frequency of miniature endplate potentials evoked by high [K+], but not that evoked by alpha\u2010latrotoxin, was effectively antagonized by omega\u2010agatoxin IVA. 4. In the presence of omega\u2010agatoxin IVA, high frequency nerve stimulation produced facilitation of endplate currents and tetanic contractions. 5. The results suggest that, under physiological conditions, the Ca2+ necessary for nerve action potential\u2010evoked acetylcholine release is translocated via a subtype of the P\u2010type Ca2+ channel sensitive to omega\u2010agatoxin IVA.<\/jats:p>","DOI":"10.1113\/jphysiol.1995.sp020517","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T11:15:22Z","timestamp":1418814922000},"page":"283-290","source":"Crossref","is-referenced-by-count":59,"title":["Inhibition of acetylcholine release from mouse motor nerve by a P\u2010type calcium channel blocker, omega\u2010agatoxin IVA."],"prefix":"10.1113","volume":"482","author":[{"given":"S J","family":"Hong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C C","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,1,15]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1995.sp020517","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1995.sp020517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T21:49:52Z","timestamp":1698270592000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1995.sp020517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1,15]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,1,15]]}},"alternative-id":["10.1113\/jphysiol.1995.sp020517"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1995.sp020517","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1,15]]}}}