{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:25:53Z","timestamp":1791473153051,"version":"4.3.4"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1995,2,15]],"date-time":"1995-02-15T00:00:00Z","timestamp":792806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1995,2,15]]},"abstract":"<jats:p>1. The perforated patch technique with amphotericin B was used to record whole\u2010cell currents activated by hypoxia in smooth muscle cells, isolated enzymatically from pig coronary arteries. 2. Superfusion with hypoxic solution (O2 partial pressure, 25\u201040 mmHg) activated an inward current at \u201060 mV in 143 mM extracellular K+. The reversal potential of the current induced by hypoxia shifted with extracellular [K+] as expected for a K+ current, while its current\u2010voltage relation was consistent with the channels showing little voltage dependence. 3. The hypoxia\u2010induced current was inhibited by glibenclamide (10 microM), but was unaffected by charybdotoxin (50 nM). 4. In whole\u2010cell recordings at \u201060 mV in 143 mM K+ solution, openings of single channels passing a current close to \u20102 pA could sometimes be detected in normoxic solution. Openings became more frequent during the onset of the response to hypoxia, when several levels could be detected. Channels with a similar conductance were activated by hypoxia in cell\u2010attached patches. 5. Our results suggest that hypoxia activates ATP\u2010dependent K+ channels. We discuss possible mechanisms by which this activation may occur.<\/jats:p>","DOI":"10.1113\/jphysiol.1995.sp020565","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T10:57:21Z","timestamp":1418813841000},"page":"29-39","source":"Crossref","is-referenced-by-count":108,"title":["Activation of ATP\u2010dependent K+ channels by hypoxia in smooth muscle cells isolated from the pig coronary artery."],"prefix":"10.1113","volume":"483","author":[{"given":"C","family":"Dart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N B","family":"Standen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1995,2,15]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1995.sp020565","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1995.sp020565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T19:59:56Z","timestamp":1698263996000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1995.sp020565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,2,15]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,2,15]]}},"alternative-id":["10.1113\/jphysiol.1995.sp020565"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1995.sp020565","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,2,15]]}}}