{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:38:57Z","timestamp":1791398337794,"version":"4.3.3"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1995,6,15]],"date-time":"1995-06-15T00:00:00Z","timestamp":803174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1995,6,15]]},"abstract":"<jats:p>1. The effects of opioid receptor agonists and antagonists on the breathing pattern of neonatal rats were studied. Three experimental approaches were taken. In the first approach, the effects of opioid agonists and antagonists on the spontaneous respiratory neural activity generated by brainstem\u2010spinal cords isolated from neonatal rats aged 0\u20104 days postnatal (P0\u20104) maintained in vitro were studied. Secondly, similar studies were performed utilizing medullary slice preparations consisting of respiratory rhythm\u2010generating regions (pre\u2010B\u00f6tzinger complex). Thirdly, whole\u2010body plethysmographic recordings were obtained from unanaesthetized neonatal (P0\u201018) rats before and after I.P. administration of opioid\u2010receptor agonists and antagonists. 2. The mu\u2010receptor agonists morphiceptin and DAGO (Tyr\u2010D\u2010Ala\u2010Gly\u2010[NMePhe]\u2010Gly\u2010ol), when added either to the solutions bathing the brainstems of neonatal rat brainstem\u2010spinal cord preparations or bathing the medullary slice preparations, resulted in a naloxone\u2010reversible, dose\u2010dependent decrease in the frequency of respiratory rhythmic discharge. 3. The respiratory burst frequency and amplitude in vitro were unaffected by the addition of the delta\u2010opioid receptor agonist DPDPE ([D\u2010pen2,5]\u2010enkephalin) and the kappa\u2010opioid receptor agonist U50488 (trans\u2010[+]\u20103,4\u2010dichloro\u2010N\u2010methyl\u2010N\u2010(2\u2010[1\u2010 pyrrolidinyl]cyclohexyl) benzene\u2010acetamide) or the opioid receptor antagonist naloxone. 4. Intraperitoneal administration of the mu\u2010opioid receptor agonist fentanyl resulted in a naloxone\u2010reversible, dose\u2010dependent decrease in the frequency and amplitude of breathing of unanaesthetized neonatal rats (P0\u2010P10). I.P. administration of the delta\u2010opioid receptor agonist DPDPE did not affect breathing of neonatal rats until the second week postnatally. 5. We conclude that opioids suppress the frequency of neonatal rat respiration by acting via mu\u2010opioid receptors located within regions of the ventral medulla containing respiratory rhythm\u2010generating centres (the pre\u2010B\u00f6tzinger complex). delta\u2010Opioid receptor activation does not affect breathing in neonatal rats until approximately the second week postnatally.<\/jats:p>","DOI":"10.1113\/jphysiol.1995.sp020774","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T10:36:18Z","timestamp":1418812578000},"page":"845-855","source":"Crossref","is-referenced-by-count":97,"title":["Opioid depression of respiration in neonatal rats."],"prefix":"10.1113","volume":"485","author":[{"given":"J J","family":"Greer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J E","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"al-Zubaidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1995,6,15]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1995.sp020774","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1995.sp020774","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T23:43:11Z","timestamp":1698277391000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1995.sp020774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,6,15]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,6,15]]}},"alternative-id":["10.1113\/jphysiol.1995.sp020774"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1995.sp020774","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,6,15]]}}}