{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:19:21Z","timestamp":1761513561778},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1995,12,1]],"date-time":"1995-12-01T00:00:00Z","timestamp":817776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1995,12]]},"abstract":"<jats:p>1. Voltage\u2010dependent calcium currents were measured at room temperature using whole\u2010cell patch clamp in acutely isolated somata and axon terminals of the magnocellular neurosecretory cells (MNCs) from the rat supraoptic nucleus. 2. Administration of omega\u2010agatoxin IVA (omega\u2010Aga IVA) blocked a high\u2010threshold non\u2010inactivating current. This current has an IC50 for omega\u2010Aga IVA of 3 nM; no other types of currents were blocked at doses of up to 500 nM. 3. In the axon terminals omega\u2010Aga IVA blocked a high\u2010threshold current that inactivates markedly (tau approximately 448 ms), and has a much lower sensitivity to the toxin, with an IC50 of 270 nM. Unlike the somatic current, the effect of omega\u2010Aga IVA in the terminals is largely prevented by omega\u2010conotoxin GVIA (omega\u2010CgTX). 4. These data suggest that MNC somata express a single type of omega\u2010Aga IVA\u2010sensitive calcium current similar to the P\u2010type calcium current described in other cells. However, the omega\u2010Aga IVA\u2010sensitive current in axon terminals differs from both the P\u2010type and the recently identified Q\u2010type current in that it is also sensitive to omega\u2010CgTX. The distinct biophysical properties of the currents in somata and axon terminals may have important physiological implications.<\/jats:p>","DOI":"10.1113\/jphysiol.1995.sp021059","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T09:30:16Z","timestamp":1418808616000},"page":"383-388","source":"Crossref","is-referenced-by-count":40,"title":["Distinct omega\u2010agatoxin\u2010sensitive calcium currents in somata and axon terminals of rat supraoptic neurones."],"prefix":"10.1113","volume":"489","author":[{"given":"T E","family":"Fisher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C W","family":"Bourque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,12]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1995.sp021059","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1995.sp021059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T14:48:46Z","timestamp":1698245326000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1995.sp021059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,12]]}},"alternative-id":["10.1113\/jphysiol.1995.sp021059"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1995.sp021059","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,12]]}}}