{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T12:40:53Z","timestamp":1775997653406,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1995,12,15]],"date-time":"1995-12-15T00:00:00Z","timestamp":818985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1995,12,15]]},"abstract":"<jats:p>1. Whole\u2010cell voltage\u2010dependent Ca2+ currents recorded from chemoreceptor type I cells of the adult rat carotid body had maximum amplitudes of \u201094 pA in 10 mM Ca2+ and were half\u2010inactivated at a holding potential of \u201038 mV. Somatostatin and dopamine inhibited whole\u2010cell Ca2+ current in type I cells. 2. The dihydropyridine agonist (+)202\u2010791 increased the Ca2+ current amplitude by 106% at a step potential of \u201018 mV. The dihydropyridine antagonist nimodipine decreased the Ca2+ current amplitude by 40% from a holding potential of \u201080 mV, and by 74% from a holding potential of \u201060 mV. The nimodipine\u2010sensitive current had a maximum amplitude at a membrane potential of \u201012 mV. omega\u2010Conotoxin GVIA (omega\u2010CgTX GVIA) blocked the whole\u2010cell Ca2+ current by 40%. The omega\u2010CgTX GVIA\u2010sensitive current had a maximum amplitude at a membrane potential of +2 mV. 3. In summary, type I cells of the adult rat carotid body have dihydropyridine\u2010sensitive L\u2010type and omega\u2010conotoxin GVIA\u2010sensitive N\u2010type voltage\u2010dependent Ca2+ channels. These channels may play a role in the voltage\u2010gated entry of Ca2+ necessary for stimulus\u2010secretion coupling in response to changes in arterial PO2, PCO2 and pH. Inhibition of the Ca2+ currents by somatostatin and dopamine may alter the chemotransduction signal in type I cells.<\/jats:p>","DOI":"10.1113\/jphysiol.1995.sp021083","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T09:44:06Z","timestamp":1418809446000},"page":"689-699","source":"Crossref","is-referenced-by-count":63,"title":["L\u2010 and N\u2010type Ca2+ channels in adult rat carotid body chemoreceptor type I cells."],"prefix":"10.1113","volume":"489","author":[{"given":"M J","family":"e Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D L","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,12,15]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1995.sp021083","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1995.sp021083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T02:27:54Z","timestamp":1698287274000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1995.sp021083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,12,15]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,12,15]]}},"alternative-id":["10.1113\/jphysiol.1995.sp021083"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1995.sp021083","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,12,15]]}}}