{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:38:56Z","timestamp":1773459536768,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1996,6,15]],"date-time":"1996-06-15T00:00:00Z","timestamp":834796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1996,6,15]]},"abstract":"<jats:p>1. The effects of raising extracellular potassium concentration ([K+]o) from 3.0 to 5.3, 9.5 or 16.8 mM on chemoreceptor responses to hypoxia, hypercapnia and asphyxia were examined in a superfused in vitro rat carotid body preparation. 2. Single\u2010exponential functions with offset were fitted to the chemoreceptor discharge responses to ramp decreases in Po2. Increasing [K+]o was without effect upon the rate constants of the fitted exponential functions (P &gt; 0.20). Increasing [K+]o, significantly increased the horizontal asymptote (chemoreceptor discharge in hyperoxia) in a non\u2010linear fashion when all levels of [K+]o were included in the analysis (P &lt; 0.001) but not when a comparison was made only between 3.0 and 5.3 mM Ko+ (P &gt; 0.40). The rightward position of the response curves, as quantified by the Po2 at 50% maximum discharge, was linearly related to [K+]o but only when all levels of [K+]o were included in the analysis (P &lt; 0.03). Chemoreceptor sensitivity to [K+]o increased non\u2010linearly as [K+]o was increased but this effect was not dependent upon the Po2 (P &gt; 0.90). 4. Increasing PCO2 in hyperoxia increased chemoreceptor discharge linearly at all levels of [K+]o. Whilst discharge at any level of PCO2 was elevated by increased levels of [K+]o, raising [K+]o did not increase CO2 sensitivity (P &gt; 0.20). Similarly, increasing PCO2 did not increase chemosensitivity to [K+]o. The lack of effect of [K+]o upon CO2 chemosensitivity was also observed as Po2 was decreased to hypoxic levels (P &gt; 0.10). 5. Our data demonstrate that an elevation of [K+]o can increase chemoreceptor discharge in the in vitro carotid body in a PO2\u2010 and PCO2\u2010independent manner, suggesting that the PO2\u2010dependent effects of [K+]o, previously reported in vivo may be due to other indirect effects of [K+]o or hypoxia.<\/jats:p>","DOI":"10.1113\/jphysiol.1996.sp021426","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T08:12:25Z","timestamp":1418803945000},"page":"833-843","source":"Crossref","is-referenced-by-count":11,"title":["Extracellular potassium and chemosensitivity in the rat carotid body, in vitro."],"prefix":"10.1113","volume":"493","author":[{"given":"D R","family":"Pepper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R C","family":"Landauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1996,6,15]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1996.sp021426","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1996.sp021426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:40:23Z","timestamp":1698367223000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1996.sp021426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,6,15]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,6,15]]}},"alternative-id":["10.1113\/jphysiol.1996.sp021426"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1996.sp021426","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,6,15]]}}}