{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:49:42Z","timestamp":1769154582654,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1996,9,1]],"date-time":"1996-09-01T00:00:00Z","timestamp":841536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1996,9]]},"abstract":"<jats:p>1. In adult decerebrate spinal rats whose plantar nerves (PLN) had been transected at either postnatal day 1 (P1) or P21 the nociceptive withdrawal reflexes (NWR) of musculi extensor digitorum longus (EDL), peroneus longus (PER) and semitendinosus (ST) were characterized with respect to receptive field (RF) organization, magnitude and time course, using electromyography. Thermal (short CO2 laser pulses) and mechanical (calibrated pinch) stimulation were used. The innervation patterns in normal and lesioned adult rats were assessed by acute nerve lesions. 2. The spatial organization of the mean mechano\u2010 and thermonociceptive RFs of all the muscles studied was similar to normal in both P1\u2010 and P21\u2010lesioned rats, although in some P21\u2010lesioned rats atypical EDL RFs were encountered. 3. In P1\u2010lesioned rats thermo\u2010NWR of PER and EDL had normal magnitudes, while mechano\u2010NWR were reduced. In P21\u2010lesioned rats both thermo\u2010 and mechano\u2010NWR of these muscles had reduced magnitudes. Except for thermo\u2010NWR of ST in P1\u2010lesioned rats, which were increased, NWR of ST had normal magnitudes in both P1\u2010 and P21\u2010lesioned rats. The time course of thermonociceptive NWR of the muscles studied were near normal in both P1\u2010 and P21\u2010lesioned rats. 4. Acute nerve lesions in adult P1\u2010lesioned rats revealed an essentially abolished contribution to NWR from the PLN. Instead, the contribution to NWR from other hindpaw nerves, such as the superficial and deep peroneal nerves, was dramatically increased. By contrast, in P21\u2010lesioned rats, the regenerated PLN contributed significantly to the NWR. 5. It is concluded that despite profound alterations of plantar hindpaw innervation induced by early PLN transection the cutaneous nociceptive input to NWR attained an essentially normal spatial organization. An experience\u2010dependent mechanism is suggested to be instrumental in adapting the reflex connectivity to the peripheral innervation.<\/jats:p>","DOI":"10.1113\/jphysiol.1996.sp021602","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T07:26:00Z","timestamp":1418801160000},"page":"399-409","source":"Crossref","is-referenced-by-count":25,"title":["Developmental adaptation of withdrawal reflexes to early alteration of peripheral innervation in the rat."],"prefix":"10.1113","volume":"495","author":[{"given":"H","family":"Holmberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Schouenborg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1996,9]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1996.sp021602","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1996.sp021602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T07:26:49Z","timestamp":1698391609000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1996.sp021602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,9]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,9]]}},"alternative-id":["10.1113\/jphysiol.1996.sp021602"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1996.sp021602","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,9]]}}}