{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:20:55Z","timestamp":1792707655377,"version":"4.5.0"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1996,12,15]],"date-time":"1996-12-15T00:00:00Z","timestamp":850608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1996,12,15]]},"abstract":"<jats:p>1. Glutamate in the extracellular compartment of the striatum of freely moving rats was monitored at 5 min intervals using microdialysis and an enzyme\u2010based assay. 2. Basal levels of dialysate glutamate were 3.6 +\/\u2010 0.5 microM. Local infusion through the dialysis probe of tetrodotoxin (TTX), cadmium chloride or magnesium chloride produced no reduction in basal levels of glutamate; with the latter two there was, instead, an increase. 3. Neuronal activation stimulated by induced grooming was accompanied by an increase in total glutamate efflux of 47.5 +\/\u2010 25.0% above basal level; this increase was not reduced by local infusion of TTX. 4. We propose that the TTX\u2010insensitive release of glutamate in response to physiological stimulation is derived from glial cells and is a Ca(2+)\u2010dependent mechanism triggered by a receptor\u2010mediated release of Ca2+ from internal stores that spreads through the network of astrocytes.<\/jats:p>","DOI":"10.1113\/jphysiol.1996.sp021805","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T06:50:46Z","timestamp":1418799046000},"page":"745-751","source":"Crossref","is-referenced-by-count":64,"title":["The source of physiologically stimulated glutamate efflux from the striatum of conscious rats."],"prefix":"10.1113","volume":"497","author":[{"given":"M","family":"Miele","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M G","family":"Boutelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Fillenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1996,12,15]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1996.sp021805","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1996.sp021805","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T09:48:56Z","timestamp":1698400136000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1996.sp021805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,12,15]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,12,15]]}},"alternative-id":["10.1113\/jphysiol.1996.sp021805"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1996.sp021805","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,12,15]]}}}