{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:59:13Z","timestamp":1790841553803,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1997,3,1]],"date-time":"1997-03-01T00:00:00Z","timestamp":857174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[1997,3]]},"abstract":"<jats:p>1. Intracellular recording techniques were used to study neurotransmitter release mechanisms in postganglionic sympathetic nerve terminals of the rat isolated anococcygeus muscle. 2. Low concentrations of the N\u2010type calcium channel blocker omega\u2010conotoxin GVIA (omega\u2010CgTX GVIA) irreversibly abolished excitatory junction potentials (EJPs) evoked by trains of &lt; or = five stimuli at 10 Hz. When the frequency of stimulation was increased (10\u201050 Hz) trains of stimuli evoked EJPs even in the presence of 1 microM omega\u2010CgTX GVIA. We have termed this omega\u2010CgTX GVIA\u2010resistant release \u2018residual release\u2019. EJP amplitude in the presence of omega\u2010CgTX GVIA depended on both the frequency and number of stimuli in a train. 3. Residual release was inhibited by the P\u2010type calcium channel blocker omega\u2010agatoxin IVA (100 nM). However, even in the presence of both toxins, longer trains of stimuli could still evoke neurotransmitter release. 4. Residual release was abolished by omega\u2010conotoxin MVIIC and by the non\u2010specific calcium channel antagonist omega\u2010grammotoxin SIA. Therefore, it would appear that a heterogeneous population of calcium channels is involved in mediating neurotransmitter release from these sympathetic nerve terminals.<\/jats:p>","DOI":"10.1113\/jphysiol.1997.sp021931","type":"journal-article","created":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T06:13:09Z","timestamp":1418796789000},"page":"341-349","source":"Crossref","is-referenced-by-count":30,"title":["Multiple calcium channels control neurotransmitter release from rat postganglionic sympathetic nerve terminals."],"prefix":"10.1113","volume":"499","author":[{"given":"A B","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T C","family":"Cunnane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1997,3]]},"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.1997.sp021931","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.1997.sp021931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T21:25:43Z","timestamp":1698441943000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.1997.sp021931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,3]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,3]]}},"alternative-id":["10.1113\/jphysiol.1997.sp021931"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.1997.sp021931","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,3]]}}}