{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:39:02Z","timestamp":1790523542043,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:p>Orthostatic intolerance is common when astronauts return to Earth: after brief spaceflight, up to two\u2010thirds are unable to remain standing for 10 min. Previous research suggests that susceptible individuals are unable to increase their systemic vascular resistance and plasma noradrenaline concentrations above pre\u2010flight upright levels. In this study, we tested the hypothesis that adaptation to the microgravity of space impairs sympathetic neural responses to upright posture on Earth. We studied six astronauts \u223c72 and 23 days before and on landing day after the 16 day Neurolab space shuttle mission. We measured heart rate, arterial pressure and cardiac output, and calculated stroke volume and total peripheral resistance, during supine rest and 10 min of 60 deg upright tilt. Muscle sympathetic nerve activity was recorded in five subjects, as a direct measure of sympathetic nervous system responses. As in previous studies, mean (\u00b1<jats:sc>s.e.m<\/jats:sc>.) stroke volume was lower (46 \u00b1 5 <jats:italic>vs<\/jats:italic>. 76 \u00b1 3 ml, <jats:italic>P<\/jats:italic>= 0.017) and heart rate was higher (93 \u00b1 1 <jats:italic>vs<\/jats:italic>. 74 \u00b1 4 beats min<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic>= 0.002) during tilt after spaceflight than before spaceflight. Total peripheral resistance during tilt post flight was higher in some, but not all astronauts (1674 \u00b1 256 <jats:italic>vs<\/jats:italic>. 1372 \u00b1 62 dynes s cm<jats:sup>\u22125<\/jats:sup>, <jats:italic>P<\/jats:italic>= 0.32). No crew member exhibited orthostatic hypotension or presyncopal symptoms during the 10 min of postflight tilting. Muscle sympathetic nerve activity was higher post flight in all subjects, in supine (27 \u00b1 4 <jats:italic>vs<\/jats:italic>. 17 \u00b1 2 bursts min<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic>= 0.04) and tilted (46 \u00b1 4 <jats:italic>vs<\/jats:italic>. 38 \u00b1 3 bursts min<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic>= 0.01) positions. A strong (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>= 0.91\u20131.00) linear correlation between left ventricular stroke volume and muscle sympathetic nerve activity suggested that sympathetic responses were appropriate for the haemodynamic challenge of upright tilt and were unaffected by spaceflight. We conclude that after 16 days of spaceflight, muscle sympathetic nerve responses to upright tilt are normal.<\/jats:p>","DOI":"10.1113\/jphysiol.2001.012575","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:45:57Z","timestamp":1027773957000},"page":"331-340","source":"Crossref","is-referenced-by-count":163,"title":["Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight"],"prefix":"10.1113","volume":"538","author":[{"given":"Benjamin D.","family":"Levine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Pawelczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Ertl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Cox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie H.","family":"Zuckerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Diedrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Italo","family":"Biaggioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chester A.","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Iwase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadaaki","family":"Mano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda D.","family":"Lane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Jay C.","family":"Buckey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Cooke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedhelm J.","family":"Baisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwain L.","family":"Eckberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Gunnar","family":"Blomqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,1]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.1.98"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1971.sp009419"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.8.8.722"},{"key":"e_1_2_5_5_1","first-page":"10.1","volume-title":"Atlas of Heart Diseases, vol. 6, Heart Disease in the Presence of Disorders of other Organ Systems","author":"Blomqvist C. G.","year":"1996"},{"key":"e_1_2_5_6_1","first-page":"1025","volume-title":"Handbook of Physiology, section 2, The Cardiovascular System","author":"Blomqvist C. G.","year":"1983"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02279892"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.1.7"},{"key":"e_1_2_5_9_1","first-page":"985","article-title":"Cardiovascular deconditioning during space flight and the use of saline as a countermeasure to orthostatic intolerance","volume":"56","author":"Bungo M. W.","year":"1985","journal-title":"Aviation, Space, and Environmental Medicine"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.65.3.566"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199710000-00005"},{"key":"e_1_2_5_12_1","first-page":"R93","article-title":"Evidence for increased \u03b2\u2010adrenoreceptor responsiveness induced by 14 days of simulated microgravity in humans","volume":"273","author":"Convertino V. A.","year":"1997","journal-title":"American Journal of Physiology"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.0617t.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.012574"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.4.1178"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.012576"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-198504000-00003"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1990.70.4.963"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-4825(91)90033-6"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.cp040239"},{"key":"e_1_2_5_21_1","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1152\/jappl.1994.77.4.1776","article-title":"Spaceflight alters autonomic regulation of arterial pressure in humans","volume":"77","author":"Fritsch\u2010Yelle J. M.","year":"1994","journal-title":"Journal of Applied Physiology"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.5.2134"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1991.71.3.617"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.19.7399"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.3.914"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.2.R445"},{"key":"e_1_2_5_27_1","first-page":"142","article-title":"Vasomotor sympathetic nerve activity in men during bed rest and on orthostasis after bed rest","volume":"71","author":"Kamiya A.","year":"2000","journal-title":"Aviation, Space, and Environmental Medicine"},{"key":"e_1_2_5_28_1","first-page":"P109","article-title":"Arterial baroreflex control of sympathetic vasocontrictor traffic and orthostatic intolerance after head\u2010down bed rest","volume":"7","author":"Kamiya A.","year":"2000","journal-title":"Journal of Gravitational Physiology"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0094-5765(81)90068-0"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.81.1.105"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199610000-00040"},{"key":"e_1_2_5_32_1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1152\/jappl.1991.70.1.112","article-title":"Physical fitness and cardiovascular regulation: mechanisms of orthostatic intolerance","volume":"70","author":"Levine B. D.","year":"1991","journal-title":"Journal of Applied Physiology"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199905001-01701"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.2.517"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199505000-00012"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.19.6.628"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199610000-00036"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.8.2509"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119463"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(75)90428-X"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199505001-00181"},{"key":"e_1_2_5_42_1","first-page":"Ls95","volume-title":"Nasa\/Aiaa Life Sciences and Space Medicine Conference","author":"Pawelczyk J. A.","year":"1995"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.5.H2230"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00582309"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199408000-00014"},{"key":"e_1_2_5_46_1","first-page":"1056","article-title":"Medical experiment M\u2010171: results from the second manned Skylab mission","volume":"47","author":"Rummel J. A.","year":"1976","journal-title":"Aviation, Space, and Environmental Medicine"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02279891"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.2.612"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.277.4.R1084"},{"key":"e_1_2_5_50_1","first-page":"H1780","article-title":"Sympathetic and vascular responses to head\u2010down neck flexion in humans","volume":"272","author":"Shortt T. L.","year":"1997","journal-title":"American Journal of Physiology"},{"key":"e_1_2_5_51_1","first-page":"H1240","article-title":"Valsalva's maneuver revisited: a quantitative method yielding insights into human autonomic control","volume":"271","author":"Smith M. L.","year":"1996","journal-title":"American Journal of Physiology"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.1991.tb00452.x"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1977.sp012050"},{"key":"e_1_2_5_54_1","first-page":"88","volume-title":"Head\u2010Down Tilt Bedrest. HDT' 88 \u2013 An International Collaborative Effort In Integrated Systems Physiology","author":"Ten Harkel A. D. J.","year":"1992"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0870553"},{"key":"e_1_2_5_56_1","first-page":"203","article-title":"Noninvasive determination of cardiac output by a modified acetylene rebreathing procedure utilizing mass spectrometer measurements","volume":"48","author":"Triebwasser J. H.","year":"1977","journal-title":"Aviation, Space and Environmental Medicine"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(95)00063-4"},{"key":"e_1_2_5_58_1","first-page":"631","volume-title":"Handbook of Physiology, section 4, Environmental Physiology, vol. i, The Gravitational Environment","author":"Watenpaugh D. E.","year":"1996"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01819146"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2001.012575","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2001.012575","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/jphysiol.2001.012575","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2001.012575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T08:27:29Z","timestamp":1693816049000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2001.012575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["10.1113\/jphysiol.2001.012575"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2001.012575","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}