{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T12:34:05Z","timestamp":1789216445250,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:p>\n                    Hypoxic ventilatory and phrenic responses are reduced in adult rats (3\u20135 months old) exposed to hyperoxia for the first month of life (hyperoxia treated). We previously reported that hypoxic phrenic responses were normal in a small sample of 14\u2010 to 15\u2010month\u2010old hyperoxia\u2010treated rats, suggesting slow, spontaneous recovery. Subsequent attempts to identify the mechanism(s) underlying this spontaneous recovery of hypoxic phrenic responses led us to re\u2010evaluate our earlier conclusion. Experiments were conducted in two groups of aged Sprague\u2010Dawley rats (14\u201315 months old) which were anaesthetized, vagotomized, neuromuscularly blocked and ventilated: (1) a hyperoxia\u2010treated group raised in 60 % O\n                    <jats:sub>2<\/jats:sub>\n                    for the first 28 postnatal days; and (2) an age\u2010matched control group raised in normoxia. Increases in minute phrenic activity and integrated phrenic nerve amplitude (\u222bPhr) during isocapnic hypoxia (arterial partial pressures of O\n                    <jats:sub>2<\/jats:sub>\n                    , 60, 50 and 40 \u00b1 1 mmHg) were greater in aged control (\n                    <jats:italic>n<\/jats:italic>\n                    = 15) than hyperoxia\u2010treated rats (\n                    <jats:italic>n<\/jats:italic>\n                    = 11;\n                    <jats:italic>P<\/jats:italic>\n                    \u2a7d 0.01). Phrenic burst frequency during hypoxia was not different between groups. To examine the central integration of carotid chemoafferent inputs, steady\u2010state relationships between carotid sinus nerve (electrical) stimulation frequency and phrenic nerve activity were compared in aged control (\n                    <jats:italic>n<\/jats:italic>\n                    = 7) and hyperoxia\u2010treated rats (\n                    <jats:italic>n<\/jats:italic>\n                    = 7). Minute phrenic activity, \u222bPhr and burst frequency were not different between groups at any stimulation frequency between 0.5 and 20 Hz. Carotid body chemoreceptor function was examined by recording whole carotid sinus nerve responses to cessation of ventilation or injection of cyanide in aged control and hyperoxia\u2010treated rats. Electrical activity of the carotid sinus nerve did not change in five out of five hyperoxia\u2010treated rats in response to stimuli that evoked robust increases in carotid sinus nerve activity in five out of five control rats. Estimates of carotid body volume were lower in aged hyperoxia\u2010treated rats\n                    <jats:styled-content>\n                      (4.4 (\u00b1 0.2) \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      \u03bcm\n                      <jats:sup>3<\/jats:sup>\n                      )\n                    <\/jats:styled-content>\n                    compared to controls\n                    <jats:styled-content>\n                      (17.4 (\u00b1 1.6) \u00d7 10\n                      <jats:sup>6<\/jats:sup>\n                      \u03bcm\n                      <jats:sup>3<\/jats:sup>\n                      ;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01)\n                    <\/jats:styled-content>\n                    . We conclude that exposure to hyperoxia for the first month of life causes life\u2010long impairment of carotid chemoreceptor function and, consequently, blunted phrenic responses to hypoxia.\n                  <\/jats:p>","DOI":"10.1113\/jphysiol.2001.012908","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T08:45:57Z","timestamp":1027759557000},"page":"947-955","source":"Crossref","is-referenced-by-count":54,"title":["Life\u2010long impairment of hypoxic phrenic responses in rats following 1 month of developmental hyperoxia"],"prefix":"10.1113","volume":"538","author":[{"given":"D. D.","family":"Fuller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. W.","family":"Bavis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. H.","family":"Vidruk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.\u2010Y.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. B.","family":"Jr Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. E.","family":"Bisgard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. S.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(96)00017-5"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(05)80078-6"},{"key":"e_1_2_5_4_1","first-page":"24","article-title":"Effect of hyperoxia from birth on the carotid chemoreceptor and ventilatory responses of rats to acute hypoxia","volume":"374","author":"Eden G. J.","year":"1986","journal-title":"Journal of Physiology"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016766"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.519bn.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-4388(94)90040-X"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.2001.4.3.175"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00917.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00132-8"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1989.sp017590"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1970.sp009022"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1996.0077"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.70.2.F90"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)91288-5"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021616"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1997.sp022058"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(97)00045-5"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(97)00091-1"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.599bh.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1985.sp015631"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197011000-00003"},{"key":"e_1_2_5_23_1","first-page":"836","article-title":"Control of ventilation in adult rats hypoxic in the neonatal period","volume":"259","author":"Okubo S.","year":"1990","journal-title":"American Journal of Physiology"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00525.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/107385849700300109"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00249791"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199312000-00025"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019490"},{"key":"e_1_2_5_29_1","volume-title":"Biometry","author":"Sokal R. R.","year":"1995"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.6.2310"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0165j.x"},{"key":"e_1_2_5_32_1","first-page":"231","volume-title":"Respiratory Control Disorders in Infants and Children","author":"Weese\u2010Mayer D. E.","year":"1992"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2001.012908","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2001.012908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/jphysiol.2001.012908","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2001.012908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T03:40:39Z","timestamp":1693798839000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2001.012908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["10.1113\/jphysiol.2001.012908"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2001.012908","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1005138.60756","asserted-by":"object"}]},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,2]]}}}