{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:00:23Z","timestamp":1791316823385,"version":"4.3.1"},"reference-count":71,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p>The on\u2010 and off\u2010transient (i.e. phase II) responses of pulmonary oxygen uptake (V\u0307<jats:sub>O2<\/jats:sub>) to moderate\u2010intensity exercise (i.e. below the lactate threshold, \u03b8<jats:sub>L<\/jats:sub>) in humans has been shown to conform to both mono\u2010exponentiality and \u2018on\u2010off\u2019 symmetry, consistent with a system manifesting linear control dynamics. However above \u03b8<jats:sub>L<\/jats:sub> the V\u0307<jats:sub>O2<\/jats:sub> kinetics have been shown to be more complex: during high\u2010intensity exercise neither mono\u2010exponentiality nor \u2018on\u2010off\u2019 symmetry have been shown to appropriately characterise the V\u0307<jats:sub>O2<\/jats:sub> response. Muscle [phosphocreatine] ([PCr]) responses to exercise, however, have been proposed to be dynamically linear with respect to work rate, and to demonstrate \u2018on\u2010off\u2019 symmetry at all work intenisties. We were therefore interested in examining the kinetic characteristics of the V\u0307<jats:sub>O2<\/jats:sub> and [PCr] responses to moderate\u2010 and high\u2010intensity knee\u2010extensor exercise in order to improve our understanding of the factors involved in the putative phosphate\u2010linked control of muscle oxygen consumption. We estimated the dynamics of intramuscular [PCr] simultaneously with those of V\u0307<jats:sub>O2<\/jats:sub> in nine healthy males who performed repeated bouts of both moderate\u2010 and high\u2010intensity square\u2010wave, knee\u2010extension exercise for 6 min, inside a whole\u2010body magnetic resonance spectroscopy (MRS) system. A transmit\u2010receive surface coil placed under the right quadriceps muscle allowed estimation of intramuscular [PCr]; V\u0307<jats:sub>O2<\/jats:sub> was measured breath\u2010by\u2010breath using a custom\u2010designed turbine and a mass spectrometer system. For moderate exercise, the kinetics were well described by a simple mono\u2010exponential function (following a short cardiodynamic phase for V\u0307<jats:sub>O2,<\/jats:sub>), with time constants (\u03c4) averaging: \u03c4V\u0307<jats:sub>O2<\/jats:sub>,<jats:sub>on<\/jats:sub> 35 \u00b1 14 s (\u00b1<jats:sc>s.d.<\/jats:sc>), \u03c4[PCr]<jats:sub>on<\/jats:sub> 33 \u00b1 12 s, \u03c4V\u0307<jats:sub>O2,off<\/jats:sub> 50 \u00b1 13 s and \u03c4[PCr]<jats:sub>off<\/jats:sub> 51 \u00b1 13 s. The kinetics for both V\u0307<jats:sub>O2<\/jats:sub> and [PCr] were more complex for high\u2010intensity exercise. The fundamental phase expressing average \u03c4 values of \u03c4V\u0307<jats:sub>O2,on<\/jats:sub> 39 \u00b1 4 s, \u03c4[PCr]<jats:sub>on<\/jats:sub> 38 \u00b1 11 s, \u03c4V\u0307<jats:sub>O2,off<\/jats:sub> 51 \u00b1 6 s and \u03c4[PCr]<jats:sub>off<\/jats:sub> 47 \u00b1 11 s. An associated slow component was expressed in the on\u2010transient only for both V\u0307<jats:sub>O2<\/jats:sub> and [PCr], and averaged 15.3 \u00b1 5.4 and 13.9 \u00b1 9.1 % of the fundamental amplitudes for V\u0307<jats:sub>O2<\/jats:sub> and [PCr], respectively. In conclusion, the \u03c4 values of the fundamental component of [PCr] and V\u0307<jats:sub>O2<\/jats:sub> dynamics cohere to within 10 %, during both the on\u2010 and off\u2010transients to a constant\u2010load work rate of both moderate\u2010 and high\u2010intensity exercise. On average, \u224890 % of the magnitude of the V\u0307<jats:sub>O2<\/jats:sub> slow component during high\u2010intensity exercise is reflected within the exercising muscle by its [PCr] response.<\/jats:p>","DOI":"10.1113\/jphysiol.2001.012910","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:15:15Z","timestamp":1027898115000},"page":"991-1002","source":"Crossref","is-referenced-by-count":318,"title":["Dynamic asymmetry of phosphocreatine concentration and O<sub>2<\/sub> uptake between the on\u2010 and off\u2010transients of moderate\u2010 and high\u2010intensity exercise in humans"],"prefix":"10.1113","volume":"541","author":[{"given":"H. B.","family":"Rossiter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. A.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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