{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T16:12:31Z","timestamp":1789315951388,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>Regenerative potentials were initiated by depolarizing short segments of single bundles of circular muscle isolated from the gastric antrum of guinea\u2010pigs. When changes in [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> and membrane potential were recorded simultaneously, regenerative potentials were found to be associated with an increase in [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>, with the increase starting after a minimum latency of about 1 s. Although the increase in [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> was reduced by nifedipine, the amplitudes of the regenerative responses were little changed. Regenerative responses and associated changes in [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> were abolished by loading the preparations with the Ca<jats:sup>2+<\/jats:sup> chelator MAPTA\u2010AM. Regenerative potentials were abolished by 2\u2010aminoethoxydiphenyl borate (2APB), an inhibitor of IP<jats:sub>3<\/jats:sub> induced Ca<jats:sup>2+<\/jats:sup> release, by <jats:italic>N<\/jats:italic>\u2010ethylamaleimide (NEM), an alkylating agent which blocks activation of G\u2010proteins and were reduced in amplitude by two agents which block chloride (Cl<jats:sup>\u2212<\/jats:sup>)\u2010selective channels in many tissues. The observations suggest that membrane depolarization triggers IP<jats:sub>3<\/jats:sub> formation. This causes Ca<jats:sup>2+<\/jats:sup> release from intracellular stores which activates Ca<jats:sup>2+<\/jats:sup>\u2010dependent Cl<jats:sup>\u2212<\/jats:sup> channels.<\/jats:p>","DOI":"10.1113\/jphysiol.2001.014803","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:45:57Z","timestamp":1027773957000},"page":"907-919","source":"Crossref","is-referenced-by-count":101,"title":["Regenerative component of slow waves in the guinea\u2010pig gastric antrum involves a delayed increase in [Ca<sup>2+<\/sup>]<sub>i<\/sub> and Cl<sup>\u2212<\/sup> channels"],"prefix":"10.1113","volume":"540","author":[{"given":"G. D. S.","family":"Hirst","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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