{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:39:17Z","timestamp":1791092357768,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:p>\n                    The excitatory action of muscarine on spinal motoneurones was investigated with intracellular recordings in a slice preparation from adult turtles. In these cells muscarine is known to facilitate a persistent inward current mediated by L\u2010type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels. When this effect was blocked by nifedipine, muscarine still increased the excitability. In voltage clamp, a slowly activating outward current, generated during depolarizing voltage commands and deactivating as a tail current on return to the holding voltage, was reduced by muscarine. This outward current was activated when the voltage was stepped to potentials positive to \u221260 mV, was voltage sensitive and had a deactivation time constant of \u224880 ms. These findings are compatible with an M\u2010current. This possibility was also supported by the finding that the current was reduced by XE\u2010991 \u2010 a selective blocker of the KCNQ potassium channels underlying M\u2010currents in other cell types. Our findings suggest that an M\u2010like current, mediated by a KCNQ channel, contributes to the intrinsic response properties of motoneurones in the adult spinal cord by increasing adaptation of repetitive firing and decreasing the slope of the frequency\u2010current relation.\n                  <\/jats:p>","DOI":"10.1113\/jphysiol.2001.015982","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T08:45:57Z","timestamp":1027759557000},"page":"875-881","source":"Crossref","is-referenced-by-count":69,"title":["An M\u2010like outward current regulates the excitability of spinal motoneurones in the adult turtle"],"prefix":"10.1113","volume":"540","author":[{"given":"Aidas","family":"Alaburda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Perrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rn","family":"Hounsgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb15019.x"},{"key":"e_1_2_5_3_1","first-page":"714.4","article-title":"M\u2010like outward current in spinal motoneurons","volume":"31","author":"Alaburda A.","year":"2001","journal-title":"Society for Neuroscience Abstracts"},{"key":"e_1_2_5_4_1","first-page":"3","volume-title":"Handbook of Physiology, section 12, Exercise: Regulation and Integration of Multiple Systems","author":"Binder M. 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