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Each subunit of the tetramer contains an individual aqueous pore that permits single\u2010file passage of water molecules but interrupts the hydrogen bonding needed for passage of protons. At least 10 mammalian aquaporins have been identified, and these are selectively permeated by water (aquaporins) or water plus glycerol (aquaglyceroporins). The sites of expression coincide closely with the clinical phenotypes \u2010 ranging from congenital cataracts to nephrogenic diabetes insipidus. More than 200 members of the aquaporin family have been found in plants, microbials, invertebrates and vertebrates, and their importance to the physiology of these organisms is being uncovered.<\/jats:p>","DOI":"10.1113\/jphysiol.2002.020818","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T23:15:15Z","timestamp":1027898115000},"page":"3-16","source":"Crossref","is-referenced-by-count":984,"title":["Aquaporin water channels \u2013 from atomic structure to clinical medicine"],"prefix":"10.1113","volume":"542","author":[{"given":"Peter","family":"Agre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Landon S.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Yasui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wm B.","family":"Guggino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Petter","family":"Ottersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Fujiyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,7]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200106158"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1768-322X.1997.tb01021.x"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.16.9061"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.24.14659"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1993.265.4.F463"},{"key":"e_1_2_15_7_1","doi-asserted-by":"crossref","first-page":"17497","DOI":"10.1016\/S0021-9258(18)45408-7","article-title":"Purification and partial characterization of the Mr 30,000 integral membrane protein associated with the erythrocyte Rh(D) antigen","volume":"262","author":"Agre P.","year":"1987","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06900-8"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/75538"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00301-5"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.278.1.F29"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8140421"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02743-0"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062459"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.36.22070"},{"key":"e_1_2_15_16_1","doi-asserted-by":"crossref","first-page":"15634","DOI":"10.1016\/S0021-9258(19)37635-5","article-title":"Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules","volume":"263","author":"Denker B. 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