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Muscle biopsies were taken at rest and after 1 and 15 min of exercise. At rest, no effects on muscle metabolism were observed in response to R\u2010Alk. In the first minute of exercise, there was a delayed activation of pyruvate dehydrogenase (PDH) in R\u2010Alk compared with Con, resulting in a reduced rate of pyruvate oxidation. Also, glycogenolysis was higher in R\u2010Alk compared with Con, which was attributed to a higher availability of the monoprotonated form of inorganic phosphate (P<jats:sub>i<\/jats:sub>), resulting in an elevated rate of pyruvate production. The mismatch between pyruvate production and its oxidation resulted in net lactate accumulation. These effects were not seen after 15 min of exercise, with no further differences in muscle metabolism between conditions. The results from the present study suggest that respiratory alkalosis may play an important role in lactate accumulation during the transition from rest to exercise in acute hypoxic conditions, but that other factors mediate lactate accumulation during steady\u2010state exercise.<\/jats:p>","DOI":"10.1113\/jphysiol.2002.022764","type":"journal-article","created":{"date-parts":[[2002,9,30]],"date-time":"2002-09-30T23:42:18Z","timestamp":1033429338000},"page":"303-313","source":"Crossref","is-referenced-by-count":30,"title":["Effects of respiratory alkalosis on human skeletal muscle metabolism at the onset of submaximal exercise"],"prefix":"10.1113","volume":"544","author":[{"given":"P. J.","family":"LeBlanc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Parolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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