{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:09:09Z","timestamp":1789380549757,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p>\n                    To investigate paired pulse facilitation of corticogeniculate EPSCs, whole\u2010cell patch\u2010clamp recordings were made from principal cells in the rat dorsal lateral geniculate nucleus (dLGN)\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Thalamic slices, oriented so that both corticogeniculate and retinogeniculate axons could be stimulated, were cut from young (16\u2010 to 37\u2010day\u2010old) DA\u2010HAN rats. Corticogeniculate EPSCs displayed pronounced paired pulse facilitation at stimulus intervals up to 400 ms. The facilitation had a fast and a slow component of decay with time constants of 12 \u00b1 7 and 164 \u00b1 47 ms (means \u00b1\n                    <jats:sc>s.d<\/jats:sc>\n                    .), respectively. Maximum paired pulse ratio (EPSC\n                    <jats:sub>2<\/jats:sub>\n                    \u00d7 EPSC\n                    <jats:sub>1<\/jats:sub>\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) was 3.7 \u00b1 1.1 at the 20\u201030 ms interval. Similar to other systems, the facilitation was presynaptic. Retinogeniculate EPSCs recorded in the same dLGN cells displayed paired pulse depression at intervals up to at least 700 ms. The two types of EPSCs differed in their calcium response curves. At normal [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>o<\/jats:sub>\n                    , the corticogeniculate synapse functioned over the early rising part of a Hill function, while the retinogeniculate synapse operated over the middle and upper parts of the curve. The paired pulse ratio of corticogeniculate EPSCs was maximal at physiological [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]\n                    <jats:sub>o<\/jats:sub>\n                    . The facilitation is proposed to have an important role in the function of the corticogeniculate circuit as a neuronal amplifier.\n                  <\/jats:p>","DOI":"10.1113\/jphysiol.2002.024703","type":"journal-article","created":{"date-parts":[[2002,10,15]],"date-time":"2002-10-15T12:45:17Z","timestamp":1034685917000},"page":"477-486","source":"Crossref","is-referenced-by-count":52,"title":["Paired pulse facilitation of corticogeniculate EPSCs in the dorsal lateral geniculate nucleus of the rat investigated\n                    <i>in vitro<\/i>"],"prefix":"10.1113","volume":"544","author":[{"given":"Bj\u00f6rn","family":"Granseth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Ahlstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivert","family":"Lindstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90886-1"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00238961"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-18-05661.1996"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(00)00214-2"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.14.4586"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1990.tb00406.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-04-01374.2000"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014846"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1985.sp015821"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1985.sp015822"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00951-9"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901630106"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/280120a0"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.76.3.1800"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.061013698"},{"issue":"11","key":"e_1_2_5_17_1","first-page":"75","article-title":"Effects of extracellular calcium ions on paired pulse facilitation and depression in the dorsal lateral geniculate nucleus in vitro","volume":"12","author":"Granseth B.","year":"2000","journal-title":"European Journal of Neuroscience"},{"key":"e_1_2_5_18_1","first-page":"1195","article-title":"Augmentation of EPSCs at corticogeniculate synapses in the dorsal lateral geniculate nucleus of the rat in vitro","volume":"26","author":"Granseth B.","year":"2000","journal-title":"Society for Neuroscience Abstracts"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1961.sp006635"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1968.sp008469"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-24-09608.2001"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00608240"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/291554a0"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.7.2774"},{"key":"e_1_2_5_25_1","first-page":"21","volume-title":"Synaptic Function","author":"Magleby K. 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