{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:40:28Z","timestamp":1789911628811,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:p>Ca<jats:sup>2+<\/jats:sup> release from the sarcoplasmic reticulum (SR) in skeletal muscle in response to small depolarisations (e.g. to \u201060 mV) should be the sum of release from many isolated Ca<jats:sup>2+<\/jats:sup> release sites. Each site has one SR Ca<jats:sup>2+<\/jats:sup> release channel activated by its associated T\u2010tubular voltage sensor. The aim of this study was to evaluate whether it also includes neighbouring Ca<jats:sup>2+<\/jats:sup> release channels activated by Ca\u2010induced Ca<jats:sup>2+<\/jats:sup> release (CICR). Ca<jats:sup>2+<\/jats:sup> release in frog cut muscle fibres was estimated with the EGTA\/phenol red method. The fraction of SR Ca content ([Ca<jats:sub>SR<\/jats:sub>]) released by a 400 ms pulse to \u201060 mV (denoted <jats:italic>f<\/jats:italic><jats:sub>Ca<\/jats:sub>) provided a measure of the average Ca<jats:sup>2+<\/jats:sup> permeability of the SR associated with the pulse. In control experiments, <jats:italic>f<\/jats:italic><jats:sub>Ca<\/jats:sub> was approximately constant when [Ca<jats:sub>SR<\/jats:sub>] was 1500\u20103000 \u03bc<jats:sc>m<\/jats:sc> (plateau region) and then increased as [Ca<jats:sub>SR<\/jats:sub>] decreased, reaching a peak when [Ca<jats:sub>SR<\/jats:sub>] was 300\u2010500 \u03bc<jats:sc>m<\/jats:sc> that was 4.8 times larger on average than the plateau value. With 8 m<jats:sc>m<\/jats:sc> of the fast Ca<jats:sup>2+<\/jats:sup> buffer BAPTA in the internal solution, <jats:italic>f<\/jats:italic><jats:sub>Ca<\/jats:sub> was 5.0\u20105.3 times larger on average than the plateau value obtained before adding BAPTA when [Ca<jats:sub>SR<\/jats:sub>] was 300\u2010500 \u03bc<jats:sc>m<\/jats:sc>. In support of earlier results, 8 m<jats:sc>m<\/jats:sc> BAPTA did not affect Ca<jats:sup>2+<\/jats:sup> release in the plateau region. At intermediate values of [Ca<jats:sub>SR<\/jats:sub>], BAPTA resulted in a small, if any, increase in <jats:italic>f<\/jats:italic><jats:sub>Ca<\/jats:sub>, presumably by decreasing Ca inactivation of Ca<jats:sup>2+<\/jats:sup> release. Since BAPTA never decreased <jats:italic>f<\/jats:italic><jats:sub>Ca<\/jats:sub>, the results indicate that neighbouring channels are not activated by CICR with small depolarisations when [Ca<jats:sub>SR<\/jats:sub>] is 300\u20103000 \u03bc<jats:sc>m<\/jats:sc>.<\/jats:p>","DOI":"10.1113\/jphysiol.2002.026658","type":"journal-article","created":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:42:52Z","timestamp":1036111372000},"page":"777-791","source":"Crossref","is-referenced-by-count":11,"title":["Recruitment of Ca<sup>2+<\/sup> release channels by calcium\u2010induced Ca<sup>2+<\/sup> release does not appear to occur in isolated Ca<sup>2+<\/sup> release sites in frog skeletal muscle"],"prefix":"10.1113","volume":"544","author":[{"given":"Karine","family":"F\u00e9nelon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Pape","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.107.6.2587"},{"key":"e_1_2_5_3_1","first-page":"225","article-title":"Membrane capacitance in frog cut twitch fibers mounted in a double Vaseline\u2010gap chamber","volume":"96","author":"Chandler W. 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