{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:35:42Z","timestamp":1790678142209,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p>Recently, we reported a novel ultrasound technique to assess biomechanical properties of the oesophagus in human subjects. In the present study, we use the technique, in combination with atropine, to determine the active and passive biomechanical properties of the oesophagus in normal healthy humans. A manometric catheter equipped with a high\u2010compliance bag and a high\u2010frequency intraluminal ultrasonography probe was used to record pressure and oesophageal geometry. Oesophageal distensions with either isovolumic (5\u201320 ml water) or with isobaric (10\u201360 mmHg) technique were performed. Intra\u2010bag pressure and ultrasound images of the oesophagus were recorded simultaneously. Following injection of atropine (15 \u03bcg kg<jats:sup>\u22121<\/jats:sup>, <jats:sc>i.v<\/jats:sc>.), the oesophageal distensions were repeated. The oesophageal wall compliance, circumferential wall tension, stress, strain and elastic modulus were calculated. Atropine resulted in an increase in the oesophageal wall compliance during isobaric distension, but no change in compliance was observed during isovolumic distension. The stress\u2013strain relationship was found to be linear during both types of distension, before as well as after atropine. The Young's modulus, which is the slope of a linear stress\u2013strain relationship, was significantly higher after atropine in the isovolumic study but not in the isobaric study. The stress\u2013strain relationship of the active component (muscle contraction) was different during isovolumic and isobaric distensions but the passive components were similar. The passive and active stress\u2013strain relationships of the human oesophagus resemble those of other soft biological tissues. Furthermore, the method of oesophageal distension has significant influence on the active but not the passive biomechanical properties due to a strain\u2010rate effect.<\/jats:p>","DOI":"10.1113\/jphysiol.2002.028795","type":"journal-article","created":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:25:02Z","timestamp":1046478302000},"page":"621-628","source":"Crossref","is-referenced-by-count":25,"title":["Effect of atropine on the biomechanical properties of the oesophageal wall in 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