{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T19:24:36Z","timestamp":1694114676341},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p>Continuous positive airway pressure (CPAP) is the main treatment of the obstructive sleep apnoea syndrome (OSAS). We assessed its effects on the upper airway (UA) dynamics in response to bilateral anterior magnetic phrenic nerve stimulation (BAMPS) in 17 awake untreated OSAS patients (15 males; 52 \u00b1 7 years) whose effective CPAP (<jats:italic>P<\/jats:italic><jats:sub>eff<\/jats:sub>) had been determined beforehand by a conventional titration sleep study. All twitch\u2010related inspirations were flow\u2010limited, flow first rising to a maximum (V\u0307<jats:sub>Imax<\/jats:sub>), then decreasing to a minimum (V\u0307<jats:sub>Imin<\/jats:sub>), and then increasing again (M\u2010shaped pattern). Up to V\u0307<jats:sub>Imin<\/jats:sub>, the relationship between driving pressure (<jats:italic>P<\/jats:italic><jats:sub>d<\/jats:sub>) and flow (V\u0307) could adequately be fitted to a polynomial regression model (V\u0307=<jats:italic>k<\/jats:italic><jats:sub>1<\/jats:sub><jats:italic>P<\/jats:italic><jats:sub>d<\/jats:sub>+<jats:italic>k<\/jats:italic><jats:sub>2<\/jats:sub><jats:italic>P<\/jats:italic><jats:sub>d<\/jats:sub><jats:sup>2<\/jats:sup>; <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>= 0.71\u20100.98, <jats:styled-content><jats:italic>P<\/jats:italic> &lt; 0.0001<\/jats:styled-content>). At atmospheric pressure V\u0307<jats:sub>Imax<\/jats:sub> was 700 \u00b1 377 ml s<jats:sup>\u22121<\/jats:sup>, V\u0307<jats:sub>Imin<\/jats:sub> was 458 \u00b1 306 ml s<jats:sup>\u22121<\/jats:sup>, <jats:italic>k<\/jats:italic><jats:sub>1<\/jats:sub> was 154.5 \u00b1 63.9 ml s<jats:sup>\u22121<\/jats:sup> (cmH<jats:sub>2<\/jats:sub>O)<jats:sup>\u22121<\/jats:sup>, and <jats:italic>k<\/jats:italic><jats:sub>2<\/jats:sub> was 10.7 \u00b1 7.3 ml s<jats:sup>\u22121<\/jats:sup> (cmH<jats:sub>2<\/jats:sub>O)<jats:sup>\u22121<\/jats:sup>. CPAP significantly increased V\u0307<jats:sub>Imax<\/jats:sub> and V\u0307<jats:sub>Imin<\/jats:sub> (peak values 1007 \u00b1 332 ml and 837 \u00b1 264 ml s<jats:sup>\u22121<\/jats:sup>, respectively) as well as <jats:italic>k<\/jats:italic><jats:sub>1<\/jats:sub> and <jats:italic>k<\/jats:italic><jats:sub>2<\/jats:sub> (peak values 300.9 \u00b1 178.2 ml s<jats:sup>\u22121<\/jats:sup> (cmH<jats:sub>2<\/jats:sub>O)<jats:sup>\u22121<\/jats:sup> and 55.2 \u00b1 65.3 ml s<jats:sup>\u22121<\/jats:sup> (cmH<jats:sub>2<\/jats:sub>O)<jats:sup>\u22121<\/jats:sup>, respectively). With increasing CPAP, <jats:italic>k<\/jats:italic><jats:sub>1<\/jats:sub>\/<jats:italic>k<\/jats:italic><jats:sub>2<\/jats:sub> increased up to a peak value before decreasing. We defined as <jats:italic>P<\/jats:italic><jats:sub>eff,stim<\/jats:sub> the CPAP value corresponding to the highest <jats:italic>k<\/jats:italic><jats:sub>1<\/jats:sub>\/<jats:italic>k<\/jats:italic><jats:sub>2<\/jats:sub> value. <jats:italic>P<\/jats:italic><jats:sub>eff,stim<\/jats:sub> was correlated with <jats:italic>P<\/jats:italic><jats:sub>eff<\/jats:sub> (<jats:italic>P<\/jats:italic><jats:sub>eff<\/jats:sub>= 7.0 \u00b1 2.0; <jats:italic>P<\/jats:italic><jats:sub>eff,stim<\/jats:sub>= 6.4 \u00b1 2.6 cmH<jats:sub>2<\/jats:sub>O; <jats:styled-content><jats:italic>r<\/jats:italic>= 0.886<\/jats:styled-content>; 95 % CI 0.696\u20100.960, <jats:styled-content><jats:italic>P<\/jats:italic> &lt; 0.001<\/jats:styled-content>). We conclude that CPAP improves UA dynamics in OSAS and that the therapeutic CPAP to apply can be predicted during wakefulness using BAMPS.<\/jats:p>","DOI":"10.1113\/jphysiol.2002.029215","type":"journal-article","created":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T03:57:03Z","timestamp":1041393423000},"page":"279-287","source":"Crossref","is-referenced-by-count":7,"title":["Effects of continuous positive airway pressure on upper airway inspiratory dynamics in awake patients with sleep\u2010disordered breathing"],"prefix":"10.1113","volume":"546","author":[{"given":"E.","family":"V\u00e9rin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Similowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"S\u00e9ri\u00e8s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,1]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1843.1999.00159.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/22.5.667"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.20.2655"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.66.4.1766"},{"key":"e_1_2_5_6_1","first-page":"788","article-title":"A simple method for assessing the validity of the esophageal balloon technique","volume":"126","author":"Baydur A","year":"1982","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.9.741"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1152\/jappl.2000.88.1.54","article-title":"Twitch transdiaphragmatic pressure depends critically on thoracoabdominal configuration","volume":"88","author":"Chen R","year":"2000","journal-title":"J Appl Physiol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.1998.tb00112.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.6.8665063"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.94.5.1023"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2001.0158"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.104.3.781"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.27.020176.002341"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.2.8049834"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.61.4.1403"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.69.2.443"},{"key":"e_1_2_5_19_1","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1152\/jappl.1988.64.5.1930","article-title":"Characteristics of the upper airway pressure\u2010flow relationship during sleep","volume":"64","author":"Hudgel DW","year":"1988","journal-title":"J Appl Physiol"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.75.1.148"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.96.6.1364"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.2000.0869"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.98.11051121"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.6_Pt_1.1526"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.4.8887614"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.2.7633730"},{"key":"e_1_2_5_27_1","first-page":"709","article-title":"A new biometrical procedure for testing the equality of measurements from two different analytical methods. 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