{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:27:59Z","timestamp":1773296879343,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:p>The obstructive sleep apnoea syndrome (OSA) is a disorder characterised by repetitive closure and re\u2010opening of the upper airway during sleep. Upper airway luminal patency is influenced by a number of factors including: intraluminal air pressure, upper airway dilator muscle activity, surrounding extraluminal tissue pressure, and also surface forces which can potentially act within the liquid layer lining the upper airway. The aim of the present study was to examine the role of upper airway mucosal lining liquid (UAL) surface tension (\u03b3) in the control of upper airway patency. Upper airway opening (<jats:italic>P<\/jats:italic><jats:sub>O<\/jats:sub>) and closing pressures (<jats:italic>P<\/jats:italic><jats:sub>C<\/jats:sub>) were measured in 25 adult male, supine, tracheostomised, mechanically ventilated, anaesthetised (sodium pentabarbitone), New Zealand White rabbits before (control) and after instillation of 0.5 ml of either 0.9 % saline (<jats:styled-content><jats:italic>n<\/jats:italic>= 9<\/jats:styled-content>) or an exogenous surfactant (<jats:italic>n<\/jats:italic>= 16; Exosurf Neonatal) into the pharyngeal airway. The \u03b3 of UAL (0.2 \u03bcl) was quantified using the \u2018pull\u2010off\u2019 force technique in which \u03b3 is measured as the force required to separate two curved silica discs bridged by the liquid sample. The \u03b3 of UAL decreased after instillation of surfactant from 54.1 \u00b1 1.7 mN m<jats:sup>\u22121<\/jats:sup> (control; mean \u00b1<jats:sc>s.e.m.<\/jats:sc>) to 49.2 \u00b1 2.1 mN m<jats:sup>\u22121<\/jats:sup> (surfactant; <jats:styled-content><jats:italic>P<\/jats:italic> &lt; 0.04<\/jats:styled-content>). Compared with control, <jats:italic>P<\/jats:italic><jats:sub>O<\/jats:sub> increased significantly (<jats:italic>P<\/jats:italic> &lt; 0.04; paired <jats:italic>t<\/jats:italic> test, <jats:styled-content><jats:italic>n<\/jats:italic>= 9<\/jats:styled-content>) from 6.2 \u00b1 0.9 to 9.6 \u00b1 1.2 cmH<jats:sub>2<\/jats:sub>O with saline, and decreased significantly (<jats:italic>P<\/jats:italic> &lt; 0.05, <jats:styled-content><jats:italic>n<\/jats:italic>= 16<\/jats:styled-content>) from 6.6 \u00b1 0.4 to 5.5 \u00b1 0.6 cmH<jats:sub>2<\/jats:sub>O with surfactant instillation. Findings tended to be similar for <jats:italic>P<\/jats:italic><jats:sub>C<\/jats:sub>. Change in both <jats:italic>P<\/jats:italic><jats:sub>O<\/jats:sub> and <jats:italic>P<\/jats:italic><jats:sub>C<\/jats:sub> showed a strong positive correlation with the change in \u03b3 of UAL (both <jats:styled-content><jats:italic>r<\/jats:italic> &gt; 0.70, <jats:italic>P<\/jats:italic> &lt; 0.001<\/jats:styled-content>). In conclusion, the patency of the upper airway in rabbits is partially influenced by the \u03b3 of UAL. These findings suggest a role for UAL surface properties in the pathophysiology of OSA.<\/jats:p>","DOI":"10.1113\/jphysiol.2002.031013","type":"journal-article","created":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:25:02Z","timestamp":1046478302000},"page":"603-611","source":"Crossref","is-referenced-by-count":40,"title":["Decreased Surface Tension of Upper Airway Mucosal Lining Liquid Increases Upper Airway Patency in Anaesthetised Rabbits"],"prefix":"10.1113","volume":"547","author":[{"given":"Jason P.","family":"Kirkness","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo K.","family":"Christenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah 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