{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:47:39Z","timestamp":1760852859508},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p>Whole\u2010cell patch\u2010clamp recordings of GABAergic IPSCs were made from cholinergic interneurones in slices of striatum from developing rats aged 21\u201060 days postnatal. In addition, the Ca<jats:sup>2+<\/jats:sup> channel subtypes involved in synaptic transmission, as well as dopamine (DA)\u2010induced presynaptic inhibition, were investigated pharmacologically with development by bath application of Ca<jats:sup>2+<\/jats:sup> channel blockers and DA receptor agonists. The IPSC amplitude was reduced by \u03c9\u2010conotoxin GVIA (\u03c9\u2010CgTX) or \u03c9\u2010agatoxin TK (\u03c9\u2010Aga\u2010TK) across the whole age range, suggesting that multiple types of Ca<jats:sup>2+<\/jats:sup> channels mediate transmission of the synapse. The IPSC fraction reduced by \u03c9\u2010CgTX significantly decreased, whereas that reduced by \u03c9\u2010Aga\u2010TK remained unchanged with development. DA or quinpirole, a D<jats:sub>2<\/jats:sub>\u2010like receptor agonist, presynaptically reduced the IPSC amplitude throughout development. The DA\u2010induced inhibition decreased with age in parallel with the decrease in N\u2010type Ca<jats:sup>2+<\/jats:sup> channels. DA showed no further inhibition of IPSCs after the inhibitory effect of \u03c9\u2010CgTX had reached steady state throughout development. These results demonstrate that there is a functional link between presynaptic N\u2010type Ca<jats:sup>2+<\/jats:sup> channels and D<jats:sub>2<\/jats:sub>\u2010like DA receptors at inhibitory synapses in the striatum. They also demonstrate that the suppression of GABAergic transmission by D<jats:sub>2<\/jats:sub>\u2010like receptors is mediated by modulation of N\u2010type Ca<jats:sup>2+<\/jats:sup> channels and decreases in parallel with the developmental decline in the contribution of N\u2010type Ca<jats:sup>2+<\/jats:sup> channels to exocytosis.<\/jats:p>","DOI":"10.1113\/jphysiol.2002.031773","type":"journal-article","created":{"date-parts":[[2003,1,15]],"date-time":"2003-01-15T01:22:42Z","timestamp":1042593762000},"page":"483-490","source":"Crossref","is-referenced-by-count":28,"title":["Parallel decrease in \u03c9\u2010conotoxin\u2010sensitive transmission and dopamine\u2010induced inhibition at the striatal synapse of developing 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