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Transmural nerve stimulation evoked a fast inhibitory junction potential (fast\u2010IJP) which was followed initially by a smaller amplitude long lasting inhibitory junction potential (slow\u2010IJP) and a period of excitation. The excitatory component of the response was abolished by atropine, suggesting that it resulted from the release of acetylcholine and activation of muscarinic receptors. Fast\u2010IJPs were selectively reduced in amplitude by apamin and slow\u2010IJPs were abolished by <jats:italic>N<\/jats:italic><jats:sup>\u03c9<\/jats:sup>\u2010nitro\u2010<jats:sc>l<\/jats:sc>\u2010arginine. Slow\u2010IJPs were associated with a drop in membrane noise, suggesting that inhibition resulted from a reduced discharge of unitary potentials by intramuscular interstitial cells of Cajal (ICC<jats:sub>IM<\/jats:sub>). The chloride channel blocker, anthracene\u20109\u2010carboxylic acid, reduced the discharge of membrane noise in a manner similar to that detected during the slow\u2010IJP. When recordings were made from the antrum of <jats:italic>W\/W<jats:sup>V<\/jats:sup><\/jats:italic> mice, which lack ICC<jats:sub>IM<\/jats:sub>, the cholinergic and nitrergic components were absent, with only fast\u2010IJPs being detected. The observations suggest that neurally released nitric oxide selectively targets ICC<jats:sub>IM<\/jats:sub> causing a hyperpolarization by suppressing the discharge of unitary potentials.<\/jats:p>","DOI":"10.1113\/jphysiol.2002.033365","type":"journal-article","created":{"date-parts":[[2003,2,3]],"date-time":"2003-02-03T20:47:40Z","timestamp":1044305260000},"page":"751-763","source":"Crossref","is-referenced-by-count":106,"title":["Involvement of intramuscular interstitial cells in nitrergic inhibition in the mouse gastric antrum"],"prefix":"10.1113","volume":"546","author":[{"given":"H.","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. R.","family":"Bayguinov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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