{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T17:46:56Z","timestamp":1785260816997,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,6,1]],"date-time":"2003-06-01T00:00:00Z","timestamp":1054425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:p>To examine whether glucose ingestion during exercise affects the release of interleukin\u20106 (IL\u20106) from the contracting limb, seven men performed 120 min of semi\u2010recumbent cycling on two occasions while ingesting either 250 ml of a 6.4 % carbohydrate (GLU trial) or sweet placebo (CON trial) beverage at the onset of, and at 15 min intervals throughout, exercise. Muscle biopsies obtained before and immediately after exercise were analysed for glycogen and IL\u20106 mRNA expression. Blood samples were simultaneously obtained from a brachial artery and a femoral vein prior to and during exercise and leg blood flow was measured by thermodilution in the femoral vein. Net leg IL\u20106 release, and net leg glucose and free fatty acid (FFA) uptake, were calculated from these measurements. The arterial IL\u20106 concentration was lower (<jats:styled-content><jats:italic>P<\/jats:italic> &lt; 0.05<\/jats:styled-content>) after 120 min of exercise in GLU, but neither intramuscular glycogen nor IL\u20106 mRNA were different when comparing GLU with CON. However, net leg IL\u20106 release was attenuated (<jats:styled-content><jats:italic>P<\/jats:italic> &lt; 0.05<\/jats:styled-content>) in GLU compared with CON. This corresponded with an enhanced (<jats:styled-content><jats:italic>P<\/jats:italic> &lt; 0.05<\/jats:styled-content>) glucose uptake and a reduced (<jats:styled-content><jats:italic>P<\/jats:italic> &lt; 0.05<\/jats:styled-content>) FFA uptake in GLU. These results demonstrate that glucose ingestion during exercise attenuates leg IL\u20106 release but does not decrease intramuscular expression of IL\u20106 mRNA.<\/jats:p>","DOI":"10.1113\/jphysiol.2003.042374","type":"journal-article","created":{"date-parts":[[2003,4,22]],"date-time":"2003-04-22T00:14:24Z","timestamp":1050970464000},"page":"607-612","source":"Crossref","is-referenced-by-count":145,"title":["Glucose Ingestion Attenuates Interleukin\u20106 Release from Contracting Skeletal Muscle in Humans"],"prefix":"10.1113","volume":"549","author":[{"given":"Mark A.","family":"Febbraio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Steensberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Starkie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning B.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Krustrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels H.","family":"Secher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente K.","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1985.sp015794"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1123\/ijsnem.12.2.145"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.025148"},{"key":"e_1_2_5_5_1","article-title":"Hepatosplanchnic clearance of interleukin\u20106 in humans","author":"Febbraio MA","year":"2003","journal-title":"Am J Physiol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0876rev"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200029060-00004"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0507fje"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.019141"},{"key":"e_1_2_5_10_1","first-page":"1033","article-title":"Interleukin\u20106 production in human subcutaneous abdominal adipose tissue: effect of exercise","volume":"543","author":"Lyngs\u00f8 D","year":"2002","journal-title":"J Physiol"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1152\/jappl.1997.82.5.1662","article-title":"Carbohydrate and the cytokine response to 2. 5 h of running","volume":"82","author":"Nehlsen\u2010Cannarella SL","year":"1997","journal-title":"J Appl Physiol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01130.2002"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199805000-00005"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.022285"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.949bp.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.3.6582"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0585a.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.280.4.C769"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00633.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.015594"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00237.x"},{"key":"e_1_2_5_22_1","article-title":"Interleukin\u20106 stimulated lipolysis and fat oxidation in humans","author":"Hall G","year":"2003","journal-title":"J Clin Endocrinol Metab"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2003.042374","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2003.042374","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/jphysiol.2003.042374","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2003.042374","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T14:42:13Z","timestamp":1693838533000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2003.042374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["10.1113\/jphysiol.2003.042374"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2003.042374","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6]]}}}