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At this synapse in mice the magnitude of paired\u2010pulse facilitation and frequency\u2010dependent facilitation markedly decreased with postnatal development from 3 weeks (3W) to 9 weeks (9W). Throughout this period the mean amplitude and variance of unitary EPSCs stayed constant. By altering extracellular Ca<jats:sup>2+<\/jats:sup>\/Mg<jats:sup>2+<\/jats:sup> concentrations the paired\u2010pulse ratio could be changed to a similar extent as observed during development. However, this was accompanied by an over 30\u2010fold change in EPSC amplitude, suggesting that the developmental change in facilitation ratio cannot simply be explained by a change in release probability. With paired\u2010pulse stimulation the Ca<jats:sup>2+<\/jats:sup> transients at MF terminals, monitored using mag\u2010fura\u20105, showed a small facilitation, but its magnitude remained similar between 3W and 9W mice. Pharmacological tests using CNQX, adenosine, LY341495, H\u20107 or KN\u201062 suggested that neither presynaptic receptors (kainate, adenosine and metabotropic glutamate) nor protein kinases are responsible for the developmental change in facilitation. Nevertheless, loading the membrane\u2010permeable form of BAPTA attenuated the paired\u2010pulse facilitation in 3W mice to a much greater extent than in 9W mice, resulting in a marked reduction in age difference. These results suggest that the developmental decrease in the MF synaptic facilitation arises from a change associated with residual Ca<jats:sup>2+<\/jats:sup>, a decrease in residual Ca<jats:sup>2+<\/jats:sup> itself or a change in Ca<jats:sup>2+<\/jats:sup>\u2010binding sites involved in the facilitation. A developmental decline in facilitation ratio reduces the dynamic range of MF transmission, possibly contributing to the stabilization of hippocampal circuitry.<\/jats:p>","DOI":"10.1113\/jphysiol.2003.045948","type":"journal-article","created":{"date-parts":[[2003,9,9]],"date-time":"2003-09-09T02:32:18Z","timestamp":1063074738000},"page":"37-48","source":"Crossref","is-referenced-by-count":50,"title":["Developmental Decrease in Synaptic Facilitation at the Mouse Hippocampal Mossy Fibre 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