{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:59:24Z","timestamp":1791194364554,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p>\n                    This investigation examined the interaction between carotid baroreflex (CBR) responsiveness during head\u2010up tilt (HUT)\u2010induced central hypovolaemia and aerobic fitness. Seven average fit (AF) individuals, with a mean maximal oxygen uptake (V\u0307\n                    <jats:sub>O2<\/jats:sub>\n                    <jats:sub>max<\/jats:sub>\n                    ) of 49 \u00b1 1 (ml O\n                    <jats:sub>2<\/jats:sub>\n                    ) kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    min\n                    <jats:sup>\u22121<\/jats:sup>\n                    , and seven high fit (HF) individuals, with a V\u0307\n                    <jats:sub>O2<\/jats:sub>\n                    <jats:sub>max<\/jats:sub>\n                    of 61 \u00b1 1 (ml O\n                    <jats:sub>2<\/jats:sub>\n                    ) kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    min\n                    <jats:sup>\u22121<\/jats:sup>\n                    , voluntarily participated in the investigation. After 10\u201015 min supine, each subject was exposed to nine levels of progressively increasing HUT by 10 deg increments from \u221220 deg to +60 deg. During the final 3 min of each stage of HUT, the CBR responsiveness was measured using a rapid pulse (500 ms) train of neck pressure (NP) and neck suction (NS) ranging from +40 to \u221280 Torr. The maximal gain of the carotid\u2010HR (\n                    <jats:italic>G<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    \u2010HR) and carotid\u2010MAP (\n                    <jats:italic>G<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    \u2010MAP) baroreflex function curves was identified as measures of CBR responsiveness. During HUT\u2010induced decreases in thoracic admittance, an index of central blood volume (CBV), the\n                    <jats:italic>G<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    \u2010HR and\n                    <jats:italic>G<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    \u2010MAP of the AF subjects increased more than the\n                    <jats:italic>G<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    \u2010HR and\n                    <jats:italic>G<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    \u2010MAP of the HF subjects (\n                    <jats:styled-content>\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05\n                    <\/jats:styled-content>\n                    ). The data demonstrate that the increase in the CBR responsiveness during a tilt\u2010induced progressive unloading of the cardiopulmonary baroreceptors was attenuated in endurance\u2010trained subjects. These findings provide an explanation for the predisposition to orthostatic hypotension and intolerance in well\u2010trained athletes.\n                  <\/jats:p>","DOI":"10.1113\/jphysiol.2003.046029","type":"journal-article","created":{"date-parts":[[2003,8,29]],"date-time":"2003-08-29T21:50:26Z","timestamp":1062193826000},"page":"601-608","source":"Crossref","is-referenced-by-count":84,"title":["Carotid baroreflex responsiveness to head\u2010up tilt\u2010induced central hypovolaemia: effect of aerobic fitness"],"prefix":"10.1113","volume":"551","author":[{"given":"Shigehiko","family":"Ogoh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanos","family":"Volianitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Nissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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