{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T17:28:12Z","timestamp":1781890092435,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,12,10]],"date-time":"2003-12-10T00:00:00Z","timestamp":1071014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p>Hypoxia increases the release of neurotransmitters from chemoreceptor cells of the carotid body (CB) and the activity in the carotid sinus nerve (CSN) sensory fibers, elevating ventilatory drive. According to previous reports, perinatal hyperoxia causes CSN hypotrophy and varied diminishment of CB function and the hypoxic ventilatory response. The present study aimed to characterize the presumptive hyperoxic damage. Hyperoxic rats were born and reared for 28 days in 55%\u201360% O<jats:sub>2<\/jats:sub>; subsequent growth (to 3.5\u20134.5 months) was in a normal atmosphere. Hyperoxic and control rats (born and reared in a normal atmosphere) responded with a similar increase in ventilatory frequency to hypoxia and hypercapnia. In comparison with the controls, hyperoxic CBs showed (1) half the size, but comparable percentage area positive to tyrosine hydroxylase (chemoreceptor cells) in histological sections; (2) a twofold increase in dopamine (DA) concentration, but a 50% reduction in DA synthesis rate; (3) a 75% reduction in hypoxia\u2010evoked DA release, but normal high [K<jats:sup>+<\/jats:sup>]<jats:sub>0<\/jats:sub>\u2010evoked release; (4) a 75% reduction in the number of hypoxia\u2010sensitive CSN fibers (although responding units displayed a nearly normal hypoxic response); and (5) a smaller percentage of chemoreceptor cells that increased [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>1<\/jats:sub> in hypoxia, although responses were within the normal range. We conclude that perinatal hyperoxia causes atrophy of the CB\u2013CSN complex, resulting in a smaller number of chemoreceptor cells and fibers. Additionally, hyperoxia damages O<jats:sub>2<\/jats:sub>\u2010sensing, but not exocytotic, machinery in most surviving chemoreceptor cells. Although hyperoxic CBs contain substantially smaller numbers of chemoreceptor cells\/sensory fibers responsive to hypoxia they appear sufficient to evoke normal increases in ventilatory frequency.<\/jats:p>","DOI":"10.1113\/jphysiol.2003.049445","type":"journal-article","created":{"date-parts":[[2003,10,28]],"date-time":"2003-10-28T07:46:56Z","timestamp":1067327216000},"page":"126-144","source":"Crossref","is-referenced-by-count":35,"title":["Ventilatory responses and carotid body function in adult rats perinatally exposed to hyperoxia"],"prefix":"10.1113","volume":"554","author":[{"given":"J.","family":"Prieto\u2010Lloret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. I.","family":"Caceres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Obeso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Rocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Rigual","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T.","family":"Agapito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bustamante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Casta\u00f1eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. T.","family":"Perez\u2010Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. R.","family":"Lopez\u2010Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,12,10]]},"reference":[{"key":"e_1_2_24_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00852.2001"},{"key":"e_1_2_24_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00859.2001"},{"key":"e_1_2_24_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01043.2002"},{"key":"e_1_2_24_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(79)90083-5"},{"key":"e_1_2_24_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1996.76.3.839"},{"key":"e_1_2_24_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(83)90078-6"},{"key":"e_1_2_24_8_1","first-page":"1767","volume-title":"The Lung","author":"Cherniack NS","year":"1997"},{"key":"e_1_2_24_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-2572-1_51"},{"key":"e_1_2_24_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)80011-7"},{"key":"e_1_2_24_11_1","first-page":"297","article-title":"Nuevas observaciones sobre la innervaci\u00f3n de la region carotidea. Los quimio y preso\u2010receptores","volume":"32","author":"De Castro F","year":"1940","journal-title":"Trab Laboratory Invest Biol Uni Madrid"},{"key":"e_1_2_24_12_1","first-page":"193","volume-title":"The Carotid Body Chemoreceptors","author":"Donnelly DF","year":"1997"},{"key":"e_1_2_24_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020067"},{"key":"e_1_2_24_14_1","first-page":"24","article-title":"Effect of hyperoxia from birth on the carotid chemoreceptor and ventilatory responses of rats to acute hypoxia","volume":"374","author":"Eden GJ","year":"1986","journal-title":"J Physiol"},{"key":"e_1_2_24_15_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016765"},{"key":"e_1_2_24_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016766"},{"key":"e_1_2_24_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.519bn.x"},{"key":"e_1_2_24_18_1","first-page":"485","article-title":"Ventilatory chemosensory drive in cats, rats and guinea\u2010pigs","volume":"536","author":"Fernandez R","year":"2003","journal-title":"Adv Exp Med Biol"},{"key":"e_1_2_24_19_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014439"},{"key":"e_1_2_24_20_1","first-page":"247","volume-title":"Handbook of Physiology. The Respiratory System II","author":"Fidone S","year":"1986"},{"key":"e_1_2_24_21_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1982.sp014441"},{"key":"e_1_2_24_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.012908"},{"key":"e_1_2_24_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00917.x"},{"key":"e_1_2_24_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00128-6"},{"key":"e_1_2_24_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90357-E"},{"key":"e_1_2_24_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1994.74.4.829"},{"key":"e_1_2_24_27_1","first-page":"114","volume-title":"Pulmonary Biology in Health and Disease","author":"Gonzalez C","year":"2002"},{"key":"e_1_2_24_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1979.tb05216.x"},{"key":"e_1_2_24_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9048(02)00047-2"},{"key":"e_1_2_24_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(87)90123-8"},{"key":"e_1_2_24_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012445"},{"key":"e_1_2_24_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-2572-1_9"},{"key":"e_1_2_24_33_1","first-page":"51","volume-title":"The Cognitive Neurosciences","author":"Kaas JH","year":"1995"},{"key":"e_1_2_24_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5290.1133"},{"key":"e_1_2_24_35_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021616"},{"key":"e_1_2_24_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(97)00091-1"},{"key":"e_1_2_24_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(97)00045-5"},{"key":"e_1_2_24_38_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1997.sp022058"},{"key":"e_1_2_24_39_1","volume-title":"Biochemistry of Catecholamines. The Biochemical Method","author":"Nagatsu T","year":"1973"},{"key":"e_1_2_24_40_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.3.2010142"},{"key":"e_1_2_24_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a006880"},{"key":"e_1_2_24_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1992.263.6.C1152"},{"key":"e_1_2_24_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(00)00384-1"},{"key":"e_1_2_24_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-9280-2_65"},{"key":"e_1_2_24_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9629(96)00370-2"},{"key":"e_1_2_24_46_1","first-page":"463","article-title":"Developmental changes in chemoreceptor nerve activity and catecholamine secretion in rabbit carotid body: possible role of Na+ and Ca2+ currents","volume":"439","author":"Rigual R","year":"2000","journal-title":"Pflugers Arch \u2013 Eur J Physiol"},{"key":"e_1_2_24_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-4-00493.x"},{"key":"e_1_2_24_48_1","first-page":"293","volume-title":"The Peripheral Arterial Chemoreceptors","author":"Seidl E","year":"1975"},{"key":"e_1_2_24_49_1","first-page":"1","volume-title":"The Carotid Body Chemoreceptors","author":"Verna A","year":"1997"},{"key":"e_1_2_24_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2000.278.3.C490"},{"key":"e_1_2_24_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.63.6.2403"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2003.049445","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2003.049445","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:40:14Z","timestamp":1697056814000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2003.049445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,10]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1113\/jphysiol.2003.049445"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2003.049445","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,10]]}}}