{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:28:44Z","timestamp":1789964924822,"version":"4.0.1"},"reference-count":84,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p>Experimental denervation in animals has shown that carotid baro\u2010 and chemoreceptors play an eminent role in maintaining blood pressure and blood gas homeostasis. Denervation of carotid sinus baro\u2010 and chemoreceptors in humans may occur as a complication of invasive interventions on the neck or after experimental surgical treatment in asthma. In this topical review, the short\u2010 and long\u2010term effects of carotid baro\u2010 and chemoreceptor denervation on the control of circulation and ventilation in humans are discussed. Carotid baroreceptor denervation in humans causes a persistent decrease in vagal and sympathetic baroreflex sensitivity and an increase in blood pressure variability; however, carotid denervation does not lead to chronic hypertension. Therefore, although carotid baroreceptors contribute to short\u2010term blood pressure control, other receptors are able to maintain normal chronic blood pressure levels in the absence of carotid baroreceptors. Conversely, carotid chemoreceptor denervation leads to permanent abolition of normocapnic ventilatory responses to hypoxia and reduced ventilatory responses to hypercapnia.<\/jats:p>","DOI":"10.1113\/jphysiol.2003.052415","type":"journal-article","created":{"date-parts":[[2003,10,7]],"date-time":"2003-10-07T00:26:26Z","timestamp":1065486386000},"page":"3-11","source":"Crossref","is-referenced-by-count":155,"title":["Denervation of Carotid Baro\u2010 and Chemoreceptors in Humans"],"prefix":"10.1113","volume":"553","author":[{"given":"Henri J. L. M.","family":"Timmers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"Wieling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Karemaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques W. M.","family":"Lenders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.40.4.27"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800611014"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1979.46.4.843"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.23.4.491"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1980.49.6.964"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.3.798"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5884(05)80142-X"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1936.00170130047003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)00184-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197506)35:6<1537::AID-CNCR2820350610>3.0.CO;2-L"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.32.5.564"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197404112901502"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2000.103789"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800741113"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/oso\/9780198576938.003.0011","volume-title":"Human Baroreflexes in Health and Disease","author":"Eckberg DL","year":"1992"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331979905000409"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00246.2002"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1986.sp016196"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/108.2.423"},{"key":"e_1_2_9_21_1","first-page":"169","volume-title":"Nucleus of the Solitary Tract","author":"Felder RB","year":"2003"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112236"},{"key":"e_1_2_9_23_1","first-page":"14","article-title":"Fatal hypertensive crisis following denervation of the carotid sinus for the relief of repeated attacks of syncope","volume":"100","author":"Ford FR","year":"1956","journal-title":"John Hopkins Med J"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(99)00115-2"},{"key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1152\/jappl.1971.30.2.193","article-title":"Chemosensitivity in normal subjects, athletes, and patients with chronic airways obstruction","volume":"30","author":"Godfrey S","year":"1971","journal-title":"J Appl Physiol"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.66.2.432"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(66)90027-2"},{"key":"e_1_2_9_28_1","first-page":"161","article-title":"The role of vagal and glossopharyngeal afferent nerves in respiratory sensation, control of breathing and arterial pressure regulation in conscious man","volume":"30","author":"Guz A","year":"1966","journal-title":"Clin Sci"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1991.71.3.617"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.77.5.2360"},{"key":"e_1_2_9_31_1","volume-title":"Die Karotissinusreflexe auf Herz und Gefasse","author":"Hering HE","year":"1927"},{"key":"e_1_2_9_32_1","first-page":"400","article-title":"Sinus carotidien et reflexes respiratoires II. Influences respiratoires reflexes de l'acidose, de l'alcalose, de l'anhydride carbonique, de l'ion hydrogene et de l'anoxeme. Sinus carotidiens et echanges respiratores dans les poumons et au dela des poumons","volume":"39","author":"Heymans C","year":"1930","journal-title":"Arch Intern Pharmacodyn"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.1006"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01797615"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1965.sp007767"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1979.46.4.632"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.3.488"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.42.2.230"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.48.4.576"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.5.1072"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000017186.52382.F4"},{"key":"e_1_2_9_42_1","volume-title":"Die reflektorische Selbststeuerung des Kreislaufs","author":"Koch E","year":"1931"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(84)80409-X"},{"key":"e_1_2_9_44_1","first-page":"577","article-title":"Experimenteller Entzugelungshochdruck bei arterieller Hypertonie","volume":"38","author":"Lampen H","year":"1949","journal-title":"Zeitschrift fur Kreislaufforschung"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.274.5.H1590"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1566-0702(01)00309-5"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197111112852002"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.41.3.309"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.8.2.147"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1986.sp016272"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(72)90430-1"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.100.1.23"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.4.1299"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1996.76.1.193"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00582309"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-76366-3"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.88.6.2287"},{"issue":"3","key":"e_1_2_9_58_1","first-page":"357","article-title":"Relationship of age and blood pressure to baroreflex sensitivity and arterial compliance in man","author":"Randall OS","year":"1976","journal-title":"Clin Sci Mol Med"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90607-1"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199311113292003"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.1.328"},{"key":"e_1_2_9_62_1","first-page":"R930","article-title":"Cardiovascular and neuroendocrine responses to baroreceptor denervation in baboons","volume":"258","author":"Shade RE","year":"1990","journal-title":"Am J Physiol"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-76366-3_8"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1159\/000169790"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc1102.105744"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(80)90054-8"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.24.1.109"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1978.45.6.971"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02318378"},{"key":"e_1_2_9_70_1","first-page":"188","article-title":"Arterial barroreflex function after unilateral carotid endarterectomy","volume":"11","author":"Timmers HJ","year":"2001","journal-title":"Clin Auton Res"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02827-4"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200303000-00026"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000080495.07301.31"},{"key":"e_1_2_9_74_1","first-page":"1413","article-title":"Labiele hypertensie door iatrogene denervatie van de sinus caroticus. [Labile hypertension due to iatrogenic denervation of the carotid sinus]","volume":"145","author":"Timmers HJ","year":"2001","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_9_75_1","first-page":"67","article-title":"Effect of carotid endarterectomy on baroreflex sensitivity in man. Intraoperative studies","volume":"500","author":"Tyden G","year":"1980","journal-title":"Acta Chir Scand Suppl"},{"key":"e_1_2_9_76_1","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1152\/jappl.1992.72.3.821","article-title":"Repetitive apneas induce periodic hypertension in normal subjects through hypoxia","volume":"72","author":"Aardweg JG","year":"1992","journal-title":"J Appl Physiol"},{"issue":"11","key":"e_1_2_9_77_1","first-page":"165","article-title":"Carotid body resection in patients with severe chronic airflow limitation","volume":"23","author":"Vermeire P","year":"1987","journal-title":"Bull Eur Physiopathol Respir"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197004092821501"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.50.030188.003025"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1975.39.3.354"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.49.11.1081"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.3.656"},{"key":"e_1_2_9_83_1","first-page":"2668","article-title":"Carotid bodies and ventilatory control dynamics in man","volume":"39","author":"Whipp BJ","year":"1980","journal-title":"Fed Proc"},{"key":"e_1_2_9_84_1","first-page":"196","volume-title":"Autonomic Failure, a Textbook of Clinical Disorders of the Autonomic Nervous System","author":"Wieling W","year":"1999"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100139167"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2003.052415","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2003.052415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1113\/jphysiol.2003.052415","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2003.052415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T22:13:51Z","timestamp":1704924831000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2003.052415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11]]},"references-count":84,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["10.1113\/jphysiol.2003.052415"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2003.052415","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11]]}}}