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Pairing theta\u2010burst stimulation (TBS) with postsynaptic depolarization, we induced long\u2010term potentiation (LTP) of putative single\u2010fibre excitatory postsynaptic currents (EPSCs) in stratum oriens\/alveus (O\/A) interneurones of mouse hippocampal slices. LTP induction was absent in metabotropic glutamate receptor 1 (mGluR1) knockout mice, was correlated with the postsynaptic presence of mGluR1a, and required a postsynaptic Ca<jats:sup>2+<\/jats:sup> rise. Changes in paired\u2010pulse facilitation and coefficient of variation indicated that LTP expression involved presynaptic mechanisms. LTP was synapse specific, occurring selectively at synapses modulated by presynaptic group II, but not group III, mGluRs. Furthermore, the TBS protocol applied in O\/A induced a long\u2010term increase of polysynaptic inhibitory responses in CA1 pyramidal cells, that was absent in mGluR1 knockout mice. 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