{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:22:09Z","timestamp":1790940129831,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,4,13]],"date-time":"2004-04-13T00:00:00Z","timestamp":1081814400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p>Patients with severe spinal cord lesions that damage descending autonomic pathways generally have low resting arterial pressure but bladder or colon distension or unheeded injuries may elicit a life\u2010threatening hypertensive episode. Such episodes (known as autonomic dysreflexia) are thought to result from the loss of descending baroreflex inhibition and\/or plasticity within the spinal cord. However, it is not clear whether changes in the periphery contribute to the exaggerated reflex vasoconstriction. The effects of spinal transection at T7\u20138 on nerve\u2010 and agonist\u2010evoked contractions of the rat tail artery were investigated <jats:italic>in vitro<\/jats:italic>. Isometric contractions of arterial segments were recorded and responses of arteries from spinalized animals (\u2018spinalized arteries\u2019) and age\u2010matched and sham\u2010operated controls were compared. Two and eight weeks after transection, nerve stimulation at 0.1\u201310 Hz produced contractions of greater force and duration in spinalized arteries. At both stages, the \u03b1\u2010adrenoceptor antagonists prazosin (10 n<jats:sc>m<\/jats:sc>) and idazoxan (0.1 \u03bc<jats:sc>m<\/jats:sc>) produced less blockade of nerve\u2010evoked contraction in spinalized arteries. Two weeks after transection, spinalized arteries were supersensitive to the \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoceptor agonist phenylephrine, and the \u03b1<jats:sub>2<\/jats:sub>\u2010adrenoceptor agonist, clonidine, but 8 weeks after transection, spinalized arteries were supersensitive only to clonidine. Contractions of spinalized arteries elicited by 60 m<jats:sc>m<\/jats:sc> K<jats:sup>+<\/jats:sup> were larger and decayed more slowly at both stages. These findings demonstrate that spinal transection markedly increases nerve\u2010evoked contractions and this can, in part, be accounted for by increased reactivity of the vascular smooth muscle to vasoconstrictor agents. This hyper\u2010reactivity may contribute to the genesis of autonomic dysreflexia in patients.<\/jats:p>","DOI":"10.1113\/jphysiol.2003.056424","type":"journal-article","created":{"date-parts":[[2004,2,10]],"date-time":"2004-02-10T01:34:08Z","timestamp":1076376848000},"page":"545-555","source":"Crossref","is-referenced-by-count":54,"title":["Tail arteries from chronically spinalized rats have potentiated responses to nerve stimulation <i>in vitro<\/i>"],"prefix":"10.1113","volume":"556","author":[{"given":"Melanie","family":"Yeoh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elspeth M.","family":"McLachlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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