{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:59:43Z","timestamp":1790625583393,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,6,24]],"date-time":"2004-06-24T00:00:00Z","timestamp":1088035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:p>\n                    The amiloride\u2010insensitive salt taste receptor is the predominant transducer of salt taste in some mammalian species, including humans. The physiological, pharmacological and biochemical properties of the amiloride\u2010insensitive salt taste receptor were investigated by RT\u2010PCR, by the measurement of unilateral apical Na\n                    <jats:sup>+<\/jats:sup>\n                    fluxes in polarized rat fungiform taste receptor cells and by chorda tympani taste nerve recordings. The chorda tympani responses to NaCl, KCl, NH\n                    <jats:sub>4<\/jats:sub>\n                    Cl and CaCl\n                    <jats:sub>2<\/jats:sub>\n                    were recorded in Sprague\u2010Dawley rats, and in wild\u2010type and vanilloid receptor\u20101 (VR\u20101) knockout mice. The chorda tympani responses to mineral salts were monitored in the presence of vanilloids (resiniferatoxin and capsaicin), VR\u20101 antagonists (capsazepine and SB\u2010366791), and at elevated temperatures. The results indicate that the amiloride\u2010insensitive salt taste receptor is a constitutively active non\u2010selective cation channel derived from the VR\u20101 gene. It accounts for all of the amiloride\u2010insensitive chorda tympani taste nerve response to Na\n                    <jats:sup>+<\/jats:sup>\n                    salts and part of the response to K\n                    <jats:sup>+<\/jats:sup>\n                    , NH\n                    <jats:sub>4<\/jats:sub>\n                    <jats:sup>+<\/jats:sup>\n                    and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    salts. It is activated by vanilloids and temperature (&gt; 38\u00b0C), and is inhibited by VR\u20101 antagonists. In the presence of vanilloids, external pH and ATP lower the temperature threshold of the channel. This allows for increased salt taste sensitivity without an increase in temperature. VR\u20101 knockout mice demonstrate no functional amiloride\u2010insensitive salt taste receptor and no salt taste sensitivity to vanilloids and temperature. We conclude that the mammalian non\u2010specific salt taste receptor is a VR\u20101 variant.\n                  <\/jats:p>","DOI":"10.1113\/jphysiol.2004.065656","type":"journal-article","created":{"date-parts":[[2004,5,17]],"date-time":"2004-05-17T20:44:06Z","timestamp":1084826646000},"page":"147-159","source":"Crossref","is-referenced-by-count":236,"title":["The mammalian amiloride\u2010insensitive non\u2010specific salt taste receptor is a vanilloid receptor\u20101 variant"],"prefix":"10.1113","volume":"558","author":[{"given":"Vijay","family":"Lyall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard L.","family":"Heck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna 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