{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:27:42Z","timestamp":1778815662243,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,11,23]],"date-time":"2004-11-23T00:00:00Z","timestamp":1101168000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p>In the present investigation we examined the role of ATP\u2010sensitive potassium (K<jats:sub>ATP<\/jats:sub>) channel activity in modulating carotid baroreflex (CBR)\u2010induced vasoconstriction in the vasculature of the leg. The CBR control of mean arterial pressure (MAP) and leg vascular conductance (LVC) was determined in seven subjects (25 \u00b1 1 years, mean \u00b1<jats:sc>s.e.m.<\/jats:sc>) using the variable\u2010pressure neck collar technique at rest and during one\u2010legged knee extension exercise. The oral ingestion of glyburide (5 mg) did not change mean arterial pressure (MAP) at rest (86 <jats:italic>versus<\/jats:italic> 89 mmHg, <jats:italic>P<\/jats:italic> &gt; 0.05), but did appear to increase MAP during exercise (87 <jats:italic>versus<\/jats:italic> 92 mmHg, <jats:italic>P<\/jats:italic>= 0.053). However, the CBR\u2013MAP function curves were similar at rest before and after glyburide ingestion. The CBR\u2010mediated decrease in LVC observed at rest (\u223c39%) was attenuated during exercise in the exercising leg (\u223c15%, <jats:italic>P<\/jats:italic> &lt; 0.05). Oral glyburide ingestion partially restored CBR\u2010mediated vasoconstriction in the exercising leg (\u223c40% restoration, <jats:italic>P<\/jats:italic> &lt; 0.05) compared to control exercise. These findings indicate that K<jats:sub>ATP<\/jats:sub> channel activity modulates sympathetic vasoconstriction in humans and may prove to be an important mechanism by which functional sympatholysis operates in humans during exercise.<\/jats:p>","DOI":"10.1113\/jphysiol.2004.071993","type":"journal-article","created":{"date-parts":[[2004,9,3]],"date-time":"2004-09-03T00:13:51Z","timestamp":1094170431000},"page":"273-282","source":"Crossref","is-referenced-by-count":57,"title":["Inhibition of K<sub>ATP<\/sub> channel activity augments baroreflex\u2010mediated vasoconstriction in exercising human skeletal muscle"],"prefix":"10.1113","volume":"561","author":[{"given":"David 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