{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:43:39Z","timestamp":1781660619939,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,11,26]],"date-time":"2004-11-26T00:00:00Z","timestamp":1101427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p>Spinal cord transection produces a marked increase in the response of the isolated rat tail artery to sympathetic nerve stimulation, possibly as a result of a decrease in ongoing sympathetic activity. We have tested the effects of removing ongoing nerve activity on neurovascular transmission by cutting the preganglionic input to postganglionic neurones supplying the tail artery (decentralization). Isometric contractions to nerve stimulation were compared between decentralized arteries and those from age\u2010matched and sham\u2010operated controls. Nerve\u2010evoked responses of decentralized arteries were much larger than those of control arteries at 2 and 7 weeks post operatively. The extent of blockade of nerve\u2010evoked contraction by \u03b1\u2010adrenoceptor antagonists prazosin (10 n<jats:sc>m<\/jats:sc>) or idazoxan (0.1 \u03bc<jats:sc>m<\/jats:sc>) was reduced. Decentralized arteries were transiently supersensitive to the \u03b1<jats:sub>1<\/jats:sub>\u2010adrenoceptor agonist phenylephrine and the \u03b1<jats:sub>2<\/jats:sub>\u2010adrenoceptor agonist clonidine; the unchanged sensitivity to methoxamine and phenylephrine after 2 weeks indicated no effect on the neuronal noradrenaline uptake transporter. Decentralized arteries were hypersensitive to \u03b1,\u03b2 methylene\u2010ATP, but the P2\u2010purinoceptor antagonist suramin (0.1 m<jats:sc>m<\/jats:sc>) did not reduce nerve\u2010evoked contractions. Enlarged responses to 60 m<jats:sc>m<\/jats:sc> K<jats:sup>+<\/jats:sup> after both 2 and 7 weeks were correlated with the response of the arteries to nerve stimulation, suggesting that increased postjunctional reactivity contributes to the enhanced contraction. Comparison between data from decentralized arteries and our previous data from spinalized animals showed that the two lesions similarly potentiate nerve\u2010evoked contractions and have similar but not identical postjunctional effects. The enhanced vascular responses following a reduction in tonic nerve activity may contribute to the hypertensive episodes of autonomic dysreflexia in spinally injured patients.<\/jats:p>","DOI":"10.1113\/jphysiol.2004.074948","type":"journal-article","created":{"date-parts":[[2004,10,15]],"date-time":"2004-10-15T00:14:23Z","timestamp":1097799263000},"page":"583-596","source":"Crossref","is-referenced-by-count":42,"title":["Chronic decentralization potentiates neurovascular transmission in the isolated rat tail artery, mimicking the effects of spinal transection"],"prefix":"10.1113","volume":"561","author":[{"given":"Melanie","family":"Yeoh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elspeth M.","family":"McLachlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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