{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T12:23:59Z","timestamp":1776947039172,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,12,10]],"date-time":"2004-12-10T00:00:00Z","timestamp":1102636800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p>Electrical slow waves in gastrointestinal (GI) muscles are generated by interstitial cells of Cajal (ICC), and these events actively propagate through networks of ICC within the walls of GI organs. The mechanism by which spontaneously active pacemaker sites throughout ICC networks are entrained to produce orderly propagation of slow waves is unresolved. A three\u2010chambered partition bath was used to test the effects of agents that affect metabolism, membrane potential and voltage\u2010dependent Ca<jats:sup>2+<\/jats:sup> entry on slow wave propagation in canine antral smooth muscle strips. Slow waves evoked by electrical field stimulation actively propagated from end to end of antral muscle strips with a constant latency between two points of recording. When the central chamber of the bath was perfused with low\u2010temperature solutions, mitochondrial inhibitors, reduced extracellular Ca<jats:sup>2+<\/jats:sup> or blockers of voltage\u2010dependent Ca<jats:sup>2+<\/jats:sup> channels, active propagation failed. Depolarization or hyperpolarization of the tissue within the central chamber also blocked propagation. Blockade of propagation by reduced extracellular Ca<jats:sup>2+<\/jats:sup> and inhibitors of dihydropyridine\u2010resistant Ca<jats:sup>2+<\/jats:sup> channels suggests that voltage\u2010dependent Ca<jats:sup>2+<\/jats:sup> entry may be the \u2018entrainment factor\u2019 that facilitates active propagation of slow waves in the gastric antrum.<\/jats:p>","DOI":"10.1113\/jphysiol.2004.076067","type":"journal-article","created":{"date-parts":[[2004,10,22]],"date-time":"2004-10-22T00:14:11Z","timestamp":1098404051000},"page":"793-810","source":"Crossref","is-referenced-by-count":56,"title":["Voltage\u2010dependent calcium entry underlies propagation of slow waves in canine gastric antrum"],"prefix":"10.1113","volume":"561","author":[{"given":"Sean M.","family":"Ward","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose 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