{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:07:27Z","timestamp":1791065247610,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,21]],"date-time":"2005-02-21T00:00:00Z","timestamp":1108944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p>Whole\u2010cell patch recordings were made from parasympathetic preganglionic neurones (P\u2010PGNs) and unidentified intermediolateral (IML) neurones in thick slices of the lower lumbar and sacral spinal cord of 14\u2010 to 21\u2010day\u2010old rats. The P\u2010PGNs and IML neurones examined were similar in terms of soma sizes, input resistance and capacitance, and displayed a sag conductance as well as rebound firing. In the absence of drugs, the neurones responded with either tonic or adapting firing to depolarizing current steps. However, in the presence of the group I metabotropic glutamate receptor agonist (<jats:italic>RS<\/jats:italic>)\u20103,5\u2010dihydroxyphenylglycine (DHPG), almost half of the neurones displayed accelerating firing rates during the constant current injection, followed by a sustained after\u2010discharge. In the presence of TTX, plateau potentials were observed. The firing changes and plateaux were blocked by nifedipine, an L\u2010type Ca<jats:sup>2+<\/jats:sup> channel blocker, and (<jats:italic>S<\/jats:italic>)\u2010(\u2212)\u2010Bay K8644 was able to produce these firing changes and plateaux in the absence of DHPG, demonstrating the involvement of an L\u2010type Ca<jats:sup>2+<\/jats:sup> conductance. Ca<jats:sup>2+<\/jats:sup>\u2010activated nonspecific cationic conductances also appear to contribute to the firing changes. A few neurones displayed membrane oscillations and burst firing in the presence of DHPG. The results suggest that the firing characteristics of both P\u2010PGNs and other neurones likely to be involved in caudal spinal reflex control are not static but, rather, quite dynamic and under metabotropic glutamate receptor modulatory control. Such changes in firing patterns may be involved in normal pelvic parasympathetic reflex function during micturition, defaecation and sexual reflexes, and may contribute to the abnormal output patterns seen with loss of descending brainstem input and visceral or perineal sensory disturbances.<\/jats:p>","DOI":"10.1113\/jphysiol.2004.076802","type":"journal-article","created":{"date-parts":[[2004,12,24]],"date-time":"2004-12-24T02:26:50Z","timestamp":1103855210000},"page":"583-596","source":"Crossref","is-referenced-by-count":26,"title":["Plateau potentials and membrane oscillations in parasympathetic preganglionic neurones and intermediolateral neurones in the rat lumbosacral spinal cord"],"prefix":"10.1113","volume":"563","author":[{"given":"D.","family":"Derjean","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bertrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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