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In marked contrast to other essential vascular beds, the mechanisms mediating maintained perfusion of the umbilical circulation during hypoxaemia remain unknown. This study determined the role of calcitonin gene\u2010related peptide (CGRP) in the maintenance of umbilical blood flow during basal and hypoxaemic conditions. Under anaesthesia, five sheep fetuses were instrumented with catheters and a Transonic probe around an umbilical artery, inside the fetal abdomen, at 0.8 of gestation. Five days later, fetuses were subjected to 0.5 h hypoxaemia during either <jats:sc>i.v.<\/jats:sc> saline or a selective CGRP antagonist in randomised order. Treatment started 30 min before hypoxaemia and ran continuously until the end of the challenge. The CGRP antagonist did not alter basal blood gas or cardiovascular status in the fetus. A similar fall in <jats:italic>P<\/jats:italic><jats:sub>a,O2<\/jats:sub> occurred in fetuses during either saline (21 \u00b1 0.8 to 9 \u00b1 0.9 mmHg) or antagonist treatment (20 \u00b1 0.9 to 9 \u00b1 1.2 mmHg). Hypoxaemia during saline led to significant increases in arterial blood pressure, umbilical blood flow and umbilical vascular conductance. In marked contrast, hypoxaemia during CGRP antagonist treatment led to pronounced falls in both umbilical blood flow and umbilical vascular conductance without affecting the magnitude of the hypertensive response. In conclusion, CGRP plays an important role in the umbilical haemodynamic defence response to hypoxaemia in the late gestation fetus.<\/jats:p>","DOI":"10.1113\/jphysiol.2004.077024","type":"journal-article","created":{"date-parts":[[2004,12,21]],"date-time":"2004-12-21T01:12:48Z","timestamp":1103591568000},"page":"309-317","source":"Crossref","is-referenced-by-count":11,"title":["Calcitonin gene\u2010related peptide contributes to the umbilical haemodynamic defence response to acute hypoxaemia"],"prefix":"10.1113","volume":"563","author":[{"given":"A. S.","family":"Thakor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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