{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:19:03Z","timestamp":1777418343784,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,3,22]],"date-time":"2005-03-22T00:00:00Z","timestamp":1111449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p>This paper provides an electrical description of the generation of slow waves in the guinea\u2010pig gastric antrum. A short segment of a circular smooth muscle bundle with an attached network of myenteric interstitial cells of Cajal (ICC\u2010MY) and longitudinal muscle sheet was modelled as three electrical compartments with resistive connexions between the ICC\u2010MY compartment and each of the smooth muscle compartments. The circular smooth muscle layer contains a proportion of intramuscular interstitial cells of Cajal (ICC\u2010IM), responsible for the regenerative component of the slow wave. Hence the equivalent cell representing the circular muscle layer incorporated a mechanism, modelled as a two stage reaction, which produces an intracellular messenger. The first stage of the reaction is proposed to be activated in a voltage\u2010dependent manner as described by Hodgkin and Huxley. A similar mechanism was incorporated into the equivalent cell describing the ICC\u2010MY network. Spontaneous discrete transient depolarizations, termed unitary potentials, are detected in records taken from either bundles of circular smooth muscle containing ICC\u2010IM or from ICC\u2010MY. In the simulation the mean rate of discharge of unitary potentials was allowed to vary with the concentration of messenger according to a conventional dose\u2013effect relationship. Such a mechanism, which describes regenerative potentials generated by the circular muscle layer, also simulated the plateau component of the pacemaker potential in the ICC\u2010MY network. A voltage\u2010sensitive membrane conductance was included in the ICC\u2010MY compartment; this was used to describe the primary component of the pacemaker potential. The model generates a range of membrane potential changes with properties similar to those generated by the three cell types present in the intact tissue.<\/jats:p>","DOI":"10.1113\/jphysiol.2004.077123","type":"journal-article","created":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T02:42:56Z","timestamp":1103683376000},"page":"213-232","source":"Crossref","is-referenced-by-count":31,"title":["An electrical description of the generation of slow waves in the antrum of the guinea\u2010pig"],"prefix":"10.1113","volume":"564","author":[{"given":"F. R.","family":"Edwards","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. D. 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