{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:09:53Z","timestamp":1791216593049,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,3,8]],"date-time":"2005-03-08T00:00:00Z","timestamp":1110240000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p>Some vagal afferent nerves are thought to mediate autonomic responses evoked by noxious oesophageal stimuli and participate in the perception of pain originating in the oesophagus. However, the vagal nociceptive nerve phenotypes implicated in this function have yet to be identified. In this study, nociceptive fibres were defined by the capacity to discriminate noxious mechanical stimuli (wide range of oesophageal distension with pressure up to 100 mmHg) and detect noxious chemical stimuli (the activators of capsaicin receptor TRPV1). Using immunohistochemical techniques with retrogradely labelled oesophagus\u2010specific neurones and performing extracellular recordings from the isolated vagally innervated oesophagus, we show that in the guinea\u2010pig, the vagus nerves supply the oesophagus with a large population of nociceptive\u2010like afferent nerve fibres. Vagal nociceptive\u2010like fibres in the guinea\u2010pig oesophagus are derived from two embryonically distinct sources: neurones situated in the nodose vagal ganglia and neurones situated in the jugular vagal ganglia. Nodose (placode\u2010derived) nociceptive\u2010like fibres are exclusively C\u2010fibres sensitive to a P2X receptors agonist and rarely express the neuropeptide substance P. In contrast, jugular (neural crest\u2010derived) nociceptive\u2010like fibres include both A\u2010fibres and C\u2010fibres, are insensitive to P2X receptors agonist and mostly express substance P. The non\u2010nociceptive vagal tension mechanoreceptors are distinguished from nociceptors by their saturable response to oesophageal distension and by the lack of TRPV1. These tension mechanoreceptors are exclusively A\u2010fibres arising from the nodose ganglion. We conclude that the vagus nerves supply the guinea\u2010pig oesophagus with nociceptors in addition to tension mechanoreceptors. The vagal nociceptive\u2010like fibres in the oesophagus comprise two distinct subtypes dictated by the ganglionic location of their cell bodies.<\/jats:p>","DOI":"10.1113\/jphysiol.2004.079574","type":"journal-article","created":{"date-parts":[[2005,1,14]],"date-time":"2005-01-14T01:18:39Z","timestamp":1105665519000},"page":"831-842","source":"Crossref","is-referenced-by-count":135,"title":["Vagal afferent nerves with nociceptive properties in guinea\u2010pig oesophagus"],"prefix":"10.1113","volume":"563","author":[{"given":"Shaoyong","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley 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