{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:38:20Z","timestamp":1773459500318,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,3,8]],"date-time":"2005-03-08T00:00:00Z","timestamp":1110240000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p>We have utilized an anaesthetized rat model of insulin\u2010induced hypoglycaemia to test the hypothesis that peripheral chemoreceptor gain is augmented during hypermetabolism. Insulin infusion at 0.4 U kg <jats:sup>\u22121<\/jats:sup>min<jats:sup>\u22121<\/jats:sup> decreased blood glucose concentration significantly to 3.37 \u00b1 0.12 mmol l<jats:sup>\u22121<\/jats:sup>. Whole\u2010body metabolism and basal ventilation were elevated without increase in <jats:styled-content><jats:italic>P<\/jats:italic><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-sub-1.gif\" xlink:title=\"urn:x-wiley:00223751:media:TJP768:tex2gif-sub-1\"\/><\/jats:styled-content> (altered non\u2010significantly from the control level, to 37.3 \u00b1 2.6 mmHg). Chemoreceptor gain, measured either as spontaneous ventilatory airflow sensitivity to <jats:styled-content><jats:italic>P<\/jats:italic><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-sub-3.gif\" xlink:title=\"urn:x-wiley:00223751:media:TJP768:tex2gif-sub-3\"\/><\/jats:styled-content> during rebreathing, or by phrenic minute activity responses to altered <jats:styled-content><jats:italic>P<\/jats:italic><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/tex2gif-sub-5.gif\" xlink:title=\"urn:x-wiley:00223751:media:TJP768:tex2gif-sub-5\"\/><\/jats:styled-content> induced by varying the level of artificial ventilation, was doubled during the period of hypermetabolism. This stimulatory effect was primarily upon the mean inspiratory flow rate, or phrenic ramp component of breathing and was reduced by 75% following bilateral carotid sinus nerve section. <jats:italic>In vitro<\/jats:italic> recordings of single carotid body chemoafferents showed that reducing superfusate glucose concentration from 10 m<jats:sc>m<\/jats:sc> to 2 m<jats:sc>m<\/jats:sc> reduced CO<jats:sub>2<\/jats:sub> chemosensitivity significantly from 0.007 \u00b1 0.002 Hz mmHg<jats:sup>\u22121<\/jats:sup> to 0.001 \u00b1 0.002 Hz mmHg<jats:sup>\u22121<\/jats:sup>. Taken together, these data suggest that the hyperpnoea observed during hypermetabolism might be mediated by an increase in the CO<jats:sub>2<\/jats:sub> sensitivity of the carotid body, and this effect is not due to the insulin\u2010induced fall in blood glucose concentration.<\/jats:p>","DOI":"10.1113\/jphysiol.2004.080085","type":"journal-article","created":{"date-parts":[[2005,1,21]],"date-time":"2005-01-21T01:13:54Z","timestamp":1106270034000},"page":"883-893","source":"Crossref","is-referenced-by-count":28,"title":["Carbon dioxide sensitivity during hypoglycaemia\u2010induced, elevated metabolism in the anaesthetized rat"],"prefix":"10.1113","volume":"563","author":[{"given":"I.","family":"Bin\u2010Jaliah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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