{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:48:10Z","timestamp":1774381690067,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,7,19]],"date-time":"2005-07-19T00:00:00Z","timestamp":1121731200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:p>In urethane\u2013chloralose anaesthetized, neuromuscularly blocked, artificially ventilated rats, we demonstrated that activation of carotid chemoreceptors inhibits the elevated levels of brown adipose tissue (BAT) sympathetic nerve activity (SNA) evoked by hypothermia, by microinjection of prostaglandin E<jats:sub>2<\/jats:sub> into the medial preoptic area or by disinhibition of neurones in the raphe pallidus area (RPa). Peripheral chemoreceptor stimulation with systemic administration of NaCN (50 \u03bcg in 0.1 ml) or with hypoxic ventilation (8% O<jats:sub>2<\/jats:sub>\u201392% N<jats:sub>2<\/jats:sub>, 30 s) completely inhibited BAT SNA. Arterial chemoreceptor\u2010evoked inhibition of BAT SNA was eliminated by prior bilateral transections of the carotid sinus nerves or by prior inhibition of neurones within the commissural nucleus tractus solitarii (commNTS) with glycine (40 nmol\/80 nl) or with the GABA<jats:sub>A<\/jats:sub> receptor agonist muscimol (160 pmol\/80 nl; 77 \u00b1 10% attenuation), or by prior blockade of ionotropic excitatory amino acid receptors in the commNTS with kynurenate (8 nmol\/80 nl; 82 \u00b1 10% attenuation). Furthermore, activation of commNTS neurones following local microinjection of bicuculline (30 pmol\/60 nl) completely inhibited the elevated level of BAT SNA resulting from disinhibition of neurones in the RPa. These results demonstrate that hypoxic stimulation of arterial chemoreceptor afferents leads to an inhibition of BAT SNA and BAT thermogenesis through an EAA\u2010mediated activation of second\u2010order, arterial chemoreceptor neurones in the commNTS. Peripheral chemoreceptor\u2010evoked inhibition of BAT SNA could directly contribute to (or be permissive for) the hypoxia\u2010evoked reductions in body temperature and oxygen consumption that serve as an adaptive response to decreased oxygen availability.<\/jats:p>","DOI":"10.1113\/jphysiol.2005.086322","type":"journal-article","created":{"date-parts":[[2005,5,7]],"date-time":"2005-05-07T00:19:30Z","timestamp":1115425170000},"page":"559-573","source":"Crossref","is-referenced-by-count":93,"title":["Hypoxic activation of arterial chemoreceptors inhibits sympathetic outflow to brown adipose tissue in rats"],"prefix":"10.1113","volume":"566","author":[{"given":"C. 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