{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:38:36Z","timestamp":1791221916471,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p>We assessed segmental and global left ventricular (LV) diastolic function via tissue\u2010Doppler imaging (TDI) as well as Doppler flow variables before and after a marathon race to extend our knowledge of exercise\u2010induced changes in cardiac function. Twenty\u2010nine subjects (age 18\u201362 year) volunteered to participate and were assessed pre\u2010 and post\u2010race. Measurements of longitudinal plane TDI myocardial diastolic velocities at five sites on the mitral annulus included peak early myocardial tissue velocity (<jats:italic>E<\/jats:italic>\u2032), peak late (or atrial) myocardial tissue velocity (<jats:italic>A<\/jats:italic>\u2032) and the ratio <jats:italic>E<\/jats:italic>\u2032\/<jats:italic>A<\/jats:italic>\u2032. Standard pulsed\u2010wave Doppler transmitral and pulmonary vein flow indices were also recorded along with measurements of body mass, heart rate, blood pressures and cardiac troponin T (cTnT), a biomarker of myocyte damage. Pre\u2010 to post\u2010race changes in LV diastolic function were analysed by repeated measures ANOVA. Delta scores for LV diastolic function were correlated with each other and alterations in indices of LV loading. Diastolic longitudinal segmental and mean TDI data were altered post\u2010race such that the mean <jats:italic>E<\/jats:italic>\u2032\/<jats:italic>A<\/jats:italic>\u2032 ratio was significantly depressed (1.51 \u00b1 0.34 to 1.16 \u00b1 0.35, <jats:italic>P<\/jats:italic> &lt; 0.05). Changes in segmental and global TDI data were not related to an elevated post\u2010race HR, a decreased post\u2010race pre\u2010load or an elevated cTnT. The pulsed wave Doppler ratio of peak early transmitral flow velocity (<jats:italic>E<\/jats:italic>)\/peak late (or atrial) flow velocity (<jats:italic>A<\/jats:italic>) was also significantly reduced post\u2010race (1.75 \u00b1 0.46 to 1.05 \u00b1 0.30, <jats:italic>P<\/jats:italic> &lt; 0.05); however, it was significantly correlated with post\u2010race changes in heart rate. The lack of change in <jats:italic>E<\/jats:italic>\/<jats:italic>E<\/jats:italic>\u2032 from pre\u2010 to post\u2010race (3.4 \u00b1 0.8 and 3.3 \u00b1 0.7, respectively) suggests that the depression in diastolic function is likely to be due to altered relaxation of the left ventricle; however, the exact aetiology of this change remains to be determined.<\/jats:p>","DOI":"10.1113\/jphysiol.2005.095588","type":"journal-article","created":{"date-parts":[[2005,8,19]],"date-time":"2005-08-19T00:13:22Z","timestamp":1124410402000},"page":"305-313","source":"Crossref","is-referenced-by-count":80,"title":["Mitral annular myocardial velocity assessment of segmental left ventricular diastolic function after prolonged exercise in 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