{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:42:18Z","timestamp":1790458938449,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,2,17]],"date-time":"2006-02-17T00:00:00Z","timestamp":1140134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p>\n                    When applied\n                    <jats:italic>in vitro<\/jats:italic>\n                    to various CNS structures 5\u2010HT and\/or NMDA have been observed to generate rhythmic nervous activity. In contrast, reports of similar\n                    <jats:italic>in vivo<\/jats:italic>\n                    actions are relatively rare. Here we describe a physiological sympathetic motor rhythm regulating the thermoregulatory circulation of the rat tail (T\u2010rhythm; 0.40\u20131.20 Hz) that can be elicited following intrathecal (\n                    <jats:sc>i.t.<\/jats:sc>\n                    ) application of 5\u2010HT to an\n                    <jats:italic>in situ<\/jats:italic>\n                    \u2018isolated\u2019 spinal cord preparation (anaesthetized rats spinalized at T10\u2013T11 and cauda equina cut).\n                    <jats:sc>i.t.<\/jats:sc>\n                    injections were delivered to L1 as sympathetic neuronal activity to the tail (SNAT) arises from preganglionic neurones at T11\u2013L2. SNAT was abolished after spinal transection (\n                    <jats:italic>n<\/jats:italic>\n                    = 18) and it did not return spontaneously. The administration of 5\u2010HT (250 nmol) generated rhythmic sympathetic discharges (\n                    <jats:italic>n<\/jats:italic>\n                    = 6). The mean frequency of the T\u2010like rhythm during the highest level of activity was 0.88 \u00b1 0.04 Hz which was not significantly different from the T\u2010rhythm frequency observed in intact animals (0.77 \u00b1 0.02 Hz;\n                    <jats:italic>P<\/jats:italic>\n                    &gt; 0.05\n                    <jats:italic>n<\/jats:italic>\n                    = 16). In contrast, NMDA (1 \u03bcmol) generated an irregular tonic activity, but it failed to generate a T\u2010like rhythm (\n                    <jats:italic>n<\/jats:italic>\n                    = 9), even though the mean levels of activity were not significantly different to those produced by 5\u2010HT. However, 5\u2010HT (250 nmol) applied after NMDA generated a T\u2010like rhythm (0.95 \u00b1 0.11 Hz,\n                    <jats:italic>n<\/jats:italic>\n                    = 6). Our observations support the idea that 5\u2010HT released from rostral ventromedial medullary neurones, known to innervate sympathetic preganglionic neurones, can induce sympathetic rhythmic activity.\n                  <\/jats:p>","DOI":"10.1113\/jphysiol.2005.100677","type":"journal-article","created":{"date-parts":[[2006,1,5]],"date-time":"2006-01-05T20:14:23Z","timestamp":1136492063000},"page":"441-450","source":"Crossref","is-referenced-by-count":32,"title":["Generation of a physiological sympathetic motor rhythm in the rat following spinal application of 5\u2010HT"],"prefix":"10.1113","volume":"571","author":[{"given":"Nephtali","family":"Marina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melody","family":"Taheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael 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