{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:34:13Z","timestamp":1785234853650,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,4,5]],"date-time":"2006-04-05T00:00:00Z","timestamp":1144195200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:p>Control mechanisms for potassium (K<jats:sup>+<\/jats:sup>) excretion in humans developed in Palaeolithic times when diets were sodium poor and episodically K<jats:sup>+<\/jats:sup> rich. Nevertheless, our understanding of the regulation of K<jats:sup>+<\/jats:sup> excretion comes from experiments in rats with large sodium and K<jats:sup>+<\/jats:sup> intakes. Our objective was to identify how K<jats:sup>+<\/jats:sup> excretion was regulated when rats consumed a low NaCl diet to reflect Palaeolithic conditions. Rats that were given mineralocorticoids plus either NaCl, mannitol, or NaHCO<jats:sub>3<\/jats:sub> had a small kaliuresis. In contrast, KCl load induced a large kaliuresis and a near\u2010maximal luminal [K<jats:sup>+<\/jats:sup>] in the terminal cortical collecting duct ([K<jats:sup>+<\/jats:sup>]<jats:sub>CCD<\/jats:sub>). The time course of events was important. The rise in the [K<jats:sup>+<\/jats:sup>]<jats:sub>CCD<\/jats:sub> was prompt, but the initial kaliuresis was only modest. Over the next 4 h, kaliuresis increased markedly due solely to a higher calculated distal flow rate, which appeared to be due to diminished reabsorption of NaCl in the loop of Henle; of note, the measured papillary [K<jats:sup>+<\/jats:sup>] rose. In summary, the increase in the [K<jats:sup>+<\/jats:sup>]<jats:sub>CCD<\/jats:sub> in rats given KCl is likely to be due to an increase in the number of luminal K<jats:sup>+<\/jats:sup> channels rather than to mechanisms that are known to induce a lumen\u2010negative voltage in cortical distal nephron segments. The higher distal flow rate might be due to a higher interstitial [K<jats:sup>+<\/jats:sup>], which inhibited NaCl reabsorption in the loop of Henle. Thus, to understand which of the potential control mechanisms are operating, one must look very closely at the conditions imposed by the experimental setting.<\/jats:p>","DOI":"10.1113\/jphysiol.2005.101576","type":"journal-article","created":{"date-parts":[[2006,2,3]],"date-time":"2006-02-03T01:32:29Z","timestamp":1138930349000},"page":"493-501","source":"Crossref","is-referenced-by-count":27,"title":["Requirements for a high rate of potassium excretion in rats consuming a low electrolyte diet"],"prefix":"10.1113","volume":"572","author":[{"given":"Surinder","family":"Cheema\u2010Dhadli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih\u2010Hua","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee","family":"Keong\u2010Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamel S.","family":"Kamel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell L.","family":"Halperin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,4,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119785"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.152"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1139\/y93-017"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00006.2001"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198501313120505"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.1.F46"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.275"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80076-X"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1998.274.5.F817"},{"key":"e_1_2_5_11_1","first-page":"F192","article-title":"Luminal influences on potassium secretion: sodium concentration and fluid flow rate","volume":"236","author":"Good DW","year":"1979","journal-title":"Am J Physiol"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00750.x"},{"key":"e_1_2_5_13_1","first-page":"F607","article-title":"Regulation of the maximum rate of renal ammoniagenesis in the dog with chronic metabolic acidosis: a quantitative analysis","volume":"248","author":"Halperin M","year":"1985","journal-title":"Am J Physiol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)85044-7"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1987.54"},{"key":"e_1_2_5_16_1","first-page":"F687","article-title":"Potassium depletion increases HCO3\n                  \u2212 reabsorption in outer medullary collecting duct by activation of colonic H\u2010K\u2010ATPase","volume":"274","author":"Nakamura S","year":"1998","journal-title":"Am J Physiol"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.104.4.693"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1999.277.5.F805"},{"key":"e_1_2_5_19_1","volume-title":"Scaling: Why Is Animal Size So Important?","author":"Schmidt\u2010Nielsen K","year":"1991"},{"key":"e_1_2_5_20_1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1152\/ajplegacy.1974.226.3.501","article-title":"Medullary collecting duct function in antidiuretic and in salt or water diurectic rats","volume":"226","author":"Sonnenberg H","year":"1974","journal-title":"Am J Physiol"},{"key":"e_1_2_5_21_1","first-page":"R554","article-title":"What is responsible for the diurnal variation in potassium excretion?","volume":"36","author":"Steele A","year":"1994","journal-title":"Am J Physiol"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110609"},{"key":"e_1_2_5_23_1","first-page":"F555","article-title":"Chloride\u2010dependent potassium secretion in early and late renal distal tubules","volume":"253","author":"Velazquez H","year":"1987","journal-title":"Am J Physiol"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.66.032102.112025"},{"key":"e_1_2_5_25_1","first-page":"226","article-title":"Development of a test to evaluate the transtubular potassium concentration gradient in the cortical collecting duct in vivo","volume":"12","author":"West ML","year":"1986","journal-title":"Min Electrolyte Metab"},{"key":"e_1_2_5_26_1","first-page":"234","article-title":"New clinical approach to evaluate disorders of potassium excretion","volume":"12","author":"West ML","year":"1986","journal-title":"Min Electrolyte Metab"},{"key":"e_1_2_5_27_1","first-page":"213","article-title":"Potassium transport in the kidney: regulation and physiologic relevance of H+,K+\u2010ATPase","volume":"13","author":"Wingo CS","year":"1993","journal-title":"Sem Nephrol"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2005.101576","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2005.101576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T07:03:32Z","timestamp":1697267012000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2005.101576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1113\/jphysiol.2005.101576"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2005.101576","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"value":"0022-3751","type":"print"},{"value":"1469-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4]]}}}