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Here we show that some individual RTN neurons are characterized by highly variable mixtures of fast, slow and mixed IPSCs. Heterogeneity arose largely through differences in the contribution of an initial decay component (\u03c4<jats:sub>D<\/jats:sub>\u223c10 ms) which was insensitive to loreclezole, suggesting involvement of the GABA<jats:sub>A<\/jats:sub> receptor \u03b2<jats:sub>1<\/jats:sub> subunit. Single\u2010cell RT\u2010PCR revealed the presence of \u03b2<jats:sub>1<\/jats:sub> subunit mRNA only in those neurons whose IPSCs were dominated by a rapid and prominent initial decay phase. These data show that brief, \u03b2<jats:sub>1<\/jats:sub>\u2010dependent, loreclezole\u2010insensitive IPSCs are present in a subpopulation of RTN neurons, and suggest that striking differences in IPSC heterogeneity within single neurons can result from of the presence or absence of a single GABA<jats:sub>A<\/jats:sub> receptor subunit.<\/jats:p>","DOI":"10.1113\/jphysiol.2006.106617","type":"journal-article","created":{"date-parts":[[2006,2,10]],"date-time":"2006-02-10T01:24:27Z","timestamp":1139534667000},"page":"459-475","source":"Crossref","is-referenced-by-count":33,"title":["Fast IPSCs in rat thalamic reticular nucleus require the GABA<sub>A<\/sub> receptor \u03b2<sub>1<\/sub> subunit"],"prefix":"10.1113","volume":"572","author":[{"given":"Molly M.","family":"Huntsman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John 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