{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:20:31Z","timestamp":1791080431740,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,6,7]],"date-time":"2006-06-07T00:00:00Z","timestamp":1149638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2006,6,15]]},"abstract":"<jats:p>The purpose of this study was to describe the frequency\u2013current (<jats:italic>f\u2013I<\/jats:italic>) relationships of hindlimb \u03b1\u2010motoneurones (MNs) in both anaesthetized and decerebrate rats <jats:italic>in situ<\/jats:italic>. Sprague\u2013Dawley rats (250\u2013350 g) were anaesthetized with ketamine and xylazine (KX) or subjected to a precollicular decerebration prior to recording electrophysiological properties from sciatic nerve MNs. Motoneurones from KX\u2010anaesthetized rats had a significantly (<jats:italic>P<\/jats:italic> &lt; 0.01) hyperpolarized resting membrane potential and voltage threshold (<jats:italic>V<\/jats:italic><jats:sub>th<\/jats:sub>), increased rheobase current, and a trend (<jats:italic>P<\/jats:italic>= 0.06) for a smaller after\u2010hyperpolarization (AHP) amplitude compared to MNs from decerebrate rats. In response to 5 s ramp current injections, MNs could be categorized into four <jats:italic>f\u2013I<\/jats:italic> relationship types: (1) linear; (2) adapting; (3) linear + sustained; and (4) late acceleration. Types 3 and 4 demonstrated self\u2010sustained firing owing to activation of persistent inward current (PIC). We estimated the PIC amplitude by subtracting the current at spike derecruitment from the current at spike recruitment. Neither estimated PIC nor <jats:italic>f\u2013I<\/jats:italic> slopes differed between fast and slow MNs (slow MNs exhibited AHP half\u2010decay times &gt; 20 ms) or between MNs from KX\u2010anaesthetized and decerebrate rats. Motoneurones from KX\u2010anaesthetized rats had significantly (<jats:italic>P<\/jats:italic> &lt; 0.02) hyperpolarized ramp <jats:italic>V<\/jats:italic><jats:sub>th<\/jats:sub> values and smaller and shorter AHP amplitudes and decay times compared to MNs from decerebrate rats. Pentobarbitone decreased the estimated PIC amplitude and almost converted the <jats:italic>f\u2013I<\/jats:italic> relationship from type 3 to type 1. In summary, MNs of animals subjected to KX anaesthesia required more current for spike initiation and rhythmic discharge but retained large PICs and self\u2010sustained firing. The KX\u2010anaesthestized preparation enables direct recording of PICs in MNs from intact animals.<\/jats:p>","DOI":"10.1113\/jphysiol.2006.107292","type":"journal-article","created":{"date-parts":[[2006,4,14]],"date-time":"2006-04-14T00:25:52Z","timestamp":1144974352000},"page":"663-677","source":"Crossref","is-referenced-by-count":78,"title":["Frequency\u2013current relationships of rat hindlimb \u03b1\u2010motoneurones"],"prefix":"10.1113","volume":"573","author":[{"given":"Duane C.","family":"Button","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalan","family":"Gardiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanguy","family":"Marqueste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip F.","family":"Gardiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,6,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0713-0_27"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.013084"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10308"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.4.1955"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00230927"},{"key":"e_1_2_5_7_1","unstructured":"ButtonDB GardinerKR MarquesteT&GardinerPF(2005a).Frequency\u2010current relationships in anesthetized and decerebrated rat hindlimb motoneurones in situ. 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