{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:47:52Z","timestamp":1791330472689,"version":"4.3.1"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T00:00:00Z","timestamp":1150675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p>Absence\u2010related spike\u2010and\u2010wave discharges (SWDs) occur in the thalamocortical system during quiet wakefulness or drowsiness. In feline generalized penicillin epilepsy, SWDs develop from sleep spindles. In contrast, in genetic absence epilepsy rats from Strasbourg (GAERS), SWDs develop from wake\u2010related 5\u20139 Hz oscillations, which are distinct from spindle oscillations (7\u201315 Hz). Since these two oscillation types share common frequency bands and may contribute to SWD genesis, it is important to compare their thalamic cellular mechanisms. Under neuroleptic analgesia, in GAERS and control non\u2010epileptic rats barbiturates abolished both SWDs and 5\u20139 Hz oscillations but increased the incidence of spindle\u2010like oscillations. Within the thalamocortical circuit 5\u20139 Hz oscillations occurred more coherently than spindle\u2010like oscillations. Intracellular events associated with 5\u20139 Hz and spindle\u2010like oscillations were distinctively different in both thalamic relay and reticular neurons. In both cell types, SWDs and 5\u20139 Hz oscillations emerged from a significantly more depolarized membrane potential than spindle\u2010like oscillations. In relay neurons, 5\u20139 Hz oscillations were mainly characterized by a rhythmic depolarization, which occurred during a tonic hyperpolarization and which could trigger an apparent low\u2010threshold Ca<jats:sup>2+<\/jats:sup> potential, whereas spindle\u2010like oscillations were characterized by a rhythmic hyperpolarization. In reticular cells, SWDs and 5\u20139 Hz oscillations occurred during a tonic hyperpolarization, whereas spindle\u2010like oscillations occurred during a long\u2010lasting depolarizing envelope. The difference in the intracellular events between 5\u20139 Hz and spindle\u2010like oscillations and similarities between 5\u20139 Hz oscillations and SWDs indicate that in GAERS, 5\u20139 Hz oscillations are more pro\u2010epileptogenic than spindle\u2010like oscillations. In conclusion, the present study strongly supports the hypothesis that SWDs in GAERS are generated by a wake\u2010related corticothalamic resonance, and not by sleep\u2010related, hypersynchronous, spindle\u2010like activity originating in the thalamus.<\/jats:p>","DOI":"10.1113\/jphysiol.2006.108498","type":"journal-article","created":{"date-parts":[[2006,4,21]],"date-time":"2006-04-21T00:36:39Z","timestamp":1145579799000},"page":"209-227","source":"Crossref","is-referenced-by-count":62,"title":["Corticothalamic 5\u20139 Hz oscillations are more pro\u2010epileptogenic than sleep spindles in 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