{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:18:13Z","timestamp":1767989893557,"version":"3.49.0"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T00:00:00Z","timestamp":1154995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2006,8,15]]},"abstract":"<jats:p>Experiments were performed under Saffan anaesthesia on normoxic (N) rats and on chronically hypoxic rats exposed to 12% O<jats:sub>2<\/jats:sub> for 1, 3 or 7 days (1, 3 or 7CH rats): N rats routinely breathed 21% O<jats:sub>2<\/jats:sub> and CH rats 12% O<jats:sub>2<\/jats:sub>. The 1, 3 and 7CH rats showed resting hyperventilation relative to N rats, but baseline heart rate (HR) was unchanged and arterial blood pressure (ABP) was lowered. Femoral vascular conductance (FVC) was increased in 1 and 3CH rats, but not 7CH rats. When 1\u20137CH rats were acutely switched to breathing 21% O<jats:sub>2<\/jats:sub> for 5 min, ABP increased and FVC decreased, consistent with removal of a hypoxic dilator stimulus that is waning in 7CH rats. We propose that this is because the increase in haematocrit and vascular remodelling in skeletal muscle help restore the O<jats:sub>2<\/jats:sub> supply. The increases in FVC evoked by acute hypoxia (8% O<jats:sub>2<\/jats:sub> for 5 min) and by infusion for 5 min of \u03b1\u2010calcitonin gene\u2010related peptide (\u03b1\u2010CGRP), which are NO\u2010dependent, were particularly accentuated in 1CH, relative to N rats. The NO synthesis inhibitor <jats:sc>l<\/jats:sc>\u2010NAME increased ABP, decreased HR and greatly reduced FVC, and attenuated increases in FVC evoked by acute hypoxia and \u03b1\u2010CGRP, such that baselines and responses were similar in N and 1\u20137CH rats. We propose that in the first few days of chronic hypoxia there is tonic NO\u2010dependent vasodilatation in skeletal muscle that is associated with accentuated dilator responsiveness to acute hypoxia and dilator substances that are NO \u2010dependent.<\/jats:p>","DOI":"10.1113\/jphysiol.2006.108753","type":"journal-article","created":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T07:50:59Z","timestamp":1147420259000},"page":"263-275","source":"Crossref","is-referenced-by-count":20,"title":["The early effects of chronic hypoxia on the cardiovascular system in the rat: role of nitric oxide"],"prefix":"10.1113","volume":"575","author":[{"given":"Martin P.","family":"Walsh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice M.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.4.1635"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.25.15069"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.3.967"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/eph8802564"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.271.3.H1182"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.163af.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.151af.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.058156"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1982.62.1.262"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.1.H241"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/28.10.1513"},{"key":"e_1_2_5_13_1","first-page":"R1114","article-title":"Attenuation of systemic vasoreactivity in chronically hypoxic rats","volume":"260","author":"Doyle MP","year":"1991","journal-title":"Am J Physiol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.2.817"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0251g.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.023663"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4179(94)90104-X"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb12333.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.1.104"},{"key":"e_1_2_5_20_1","first-page":"136.2","article-title":"Changes in iNOS, VEGF and eNOS protein expression induced by chronic hypoxia in skeletal muscle in vivo. 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