{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T23:40:01Z","timestamp":1736379601447,"version":"3.32.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T00:00:00Z","timestamp":1154995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2006,8,15]]},"abstract":"<jats:p>Experiments were performed on anaesthetized normoxic (N) rats and chronically hypoxic rats that had been exposed to 12% O<jats:sub>2<\/jats:sub>for 1, 3 or 7 days (1, 3 or 7CH rats). The adenosine A<jats:sub>1<\/jats:sub>receptor antagonist DPCPX did not affect the resting hyperventilation of 1\u20137CH rats breathing 12% O<jats:sub>2<\/jats:sub>and increased resting heart rate (HR) in 1CH rats only. DPCPX partially restored the decreased baseline arterial pressure (ABP) and increased femoral vascular conductance (FVC) of 1 and 3CH rats, but had no effect in N or 7CH rats. DPCPX also attenuated the decrease in arterial blood pressure (ABP) and increase in FVC evoked by acute hypoxia in N and 1\u20137CH rats. The non\u2010selective adenosine receptor antagonist 8\u2010SPT had no further effect on baselines or cardiovascular responses to acute hypoxia, but attenuated the hypoxia\u2010evoked increase in respiratory frequency in 1\u20137CH rats. In N, and 1 and 3CH rats, the inducible nitric oxide synthase (iNOS) inhibitor aminoguanidine had no effect on baselines or increases in FVC evoked by acetylcholine. We propose: (i) that tonically released adenosine acting on A<jats:sub>1<\/jats:sub>receptors reduces HR in 1CH rats and stimulates endothelial NOS in 1 and 3CH rats to decrease ABP and increase FVC, the remaining NO\u2010dependent tonic vasodilatation being independent of iNOS activity; (ii) that in 7CH rats, tonic adenosine release has waned; (iii) that in 1\u20137CH rats, adenosine released by acute hypoxia stimulates A<jats:sub>1<\/jats:sub>but not A<jats:sub>2<\/jats:sub>receptors to produce muscle vasodilatation, and stimulates carotid body A<jats:sub>2<\/jats:sub>receptors to increase respiration.<\/jats:p>","DOI":"10.1113\/jphysiol.2006.108779","type":"journal-article","created":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T07:50:59Z","timestamp":1147420259000},"page":"277-289","source":"Crossref","is-referenced-by-count":12,"title":["The role of adenosine in the early respiratory and cardiovascular changes evoked by chronic hypoxia in the rat"],"prefix":"10.1113","volume":"575","author":[{"given":"Martin P.","family":"Walsh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice M.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(89)90015-7"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90845-Z"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.163af.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.151af.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.058156"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.507bn.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90616-Q"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1982.62.1.262"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.1.H241"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00927.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.023663"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.59.5.1428"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(82)90746-9"},{"key":"e_1_2_5_15_1","first-page":"428","article-title":"Antagonism of the cardiovascular effects of adenosine by caffeine or 8\u2010(p\u2010sulphophenyl)\u2010theophylline","volume":"240","author":"Evoniuk G","year":"1987","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_5_16_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0031-6997(24)01339-5","article-title":"Adenosine A2b receptors","volume":"49","author":"Feoktistov I","year":"1997","journal-title":"Pharmacol Rev"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/10623329709053395"},{"key":"e_1_2_5_18_1","first-page":"R332","article-title":"Regional haemodynamic effects of calcitonin gene\u2010related peptide","volume":"256","author":"Gardiner SM","year":"1989","journal-title":"Am J Physiol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1207"},{"key":"e_1_2_5_20_1","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1152\/jappl.1992.73.4.1377","article-title":"Hypoxia\u2010induced downregulation of \u03b2\u2010adrenergic receptors in rat heart","volume":"73","author":"Kacimi R","year":"1992","journal-title":"J Appl Physiol"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.75.3.1123"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1989.tb14639.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2000.279.2.L273"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1996.270.1.L164"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.6.2218"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00175797"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018847"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0034-5687(84)90081-1"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0593c.xd"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00177715"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018723"},{"key":"e_1_2_5_32_1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1152\/jappl.1978.44.5.763","article-title":"Rat as a model for human\u2010like ventilatory adaptation to chronic hypoxia","volume":"44","author":"Olson EB","year":"1978","journal-title":"J Appl Physiol"},{"key":"e_1_2_5_33_1","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1152\/jappl.1992.72.6.2354","article-title":"Ventilatory and haematopoietic responses to chronic hypoxia in two rat strains","volume":"72","author":"Ou IC","year":"1992","journal-title":"J Appl Physiol"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000025589"},{"key":"e_1_2_5_35_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0031-6997(24)01373-5","article-title":"Receptors for purines and pyrimidines","volume":"50","author":"Ralevic V","year":"1998","journal-title":"Pharmacol Rev"},{"key":"e_1_2_5_36_1","first-page":"174","article-title":"Antagonism of adenosine induced relaxation by methylxanthines in coronary artery.","volume":"295","author":"Ramagopal MV","year":"1988","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.023440"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.094854"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.28.17610"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020621"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/359843a0"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.86.5.1739"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021615"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.00261.x"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1994.sp003809"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020389"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.439bn.x"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00108a015"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.108753"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(84)90678-2"},{"key":"e_1_2_5_51_1","first-page":"H2735","article-title":"VEGF induces NO\u2010dependent hyperpermeability in coronary venules","volume":"271","author":"Wu HM","year":"1996","journal-title":"Am J Physiol"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.16.7432"}],"container-title":["The Journal of Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1113%2Fjphysiol.2006.108779","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/pdf\/10.1113\/jphysiol.2006.108779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T23:04:41Z","timestamp":1736377481000},"score":1,"resource":{"primary":{"URL":"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.1113\/jphysiol.2006.108779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,8]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,8,15]]}},"alternative-id":["10.1113\/jphysiol.2006.108779"],"URL":"https:\/\/doi.org\/10.1113\/jphysiol.2006.108779","archive":["Portico"],"relation":{},"ISSN":["0022-3751","1469-7793"],"issn-type":[{"type":"print","value":"0022-3751"},{"type":"electronic","value":"1469-7793"}],"subject":[],"published":{"date-parts":[[2006,8,8]]}}}