{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:10:39Z","timestamp":1790665839838,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,11,8]],"date-time":"2006-11-08T00:00:00Z","timestamp":1162944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Physiology"],"published-print":{"date-parts":[[2006,11,15]]},"abstract":"<jats:p>\n                    An important determinant of [H\n                    <jats:sup>+<\/jats:sup>\n                    ] in the environment of the central chemoreceptors is cerebral blood flow. Accordingly we hypothesized that a reduction of brain perfusion or a reduced cerebrovascular reactivity to CO\n                    <jats:sub>2<\/jats:sub>\n                    would lead to hyperventilation and an increased ventilatory responsiveness to CO\n                    <jats:sub>2<\/jats:sub>\n                    . We used oral indomethacin to reduce the cerebrovascular reactivity to CO\n                    <jats:sub>2<\/jats:sub>\n                    and tested the steady\u2010state hypercapnic ventilatory response to CO\n                    <jats:sub>2<\/jats:sub>\n                    in nine normal awake human subjects under normoxia and hyperoxia (50% O\n                    <jats:sub>2<\/jats:sub>\n                    ). Ninety minutes after indomethacin ingestion, cerebral blood flow velocity (CBFV) in the middle cerebral artery decreased to 77 \u00b1 5% of the initial value and the average slope of CBFV response to hypercapnia was reduced to 31% of control in normoxia (1.92\n                    <jats:italic>versus<\/jats:italic>\n                    0.59 cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    s\n                    <jats:sup>\u22121<\/jats:sup>\n                    mmHg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05) and 37% of control in hyperoxia (1.58\n                    <jats:italic>versus<\/jats:italic>\n                    0.59 cm\n                    <jats:sup>\u22121<\/jats:sup>\n                    s\n                    <jats:sup>\u22121<\/jats:sup>\n                    mmHg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). Concomitantly, indomethacin administration also caused 40\u201360% increases in the slope of the mean ventilatory response to CO\n                    <jats:sub>2<\/jats:sub>\n                    in both normoxia (1.27 \u00b1 0.31\n                    <jats:italic>versus<\/jats:italic>\n                    1.76 \u00b1 0.37 l min\n                    <jats:sup>\u22121<\/jats:sup>\n                    mmHg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05) and hyperoxia (1.08 \u00b1 0.22\n                    <jats:italic>versus<\/jats:italic>\n                    1.79 \u00b1 0.37 l min\n                    <jats:sup>\u22121<\/jats:sup>\n                    mmHg\n                    <jats:sup>\u22121<\/jats:sup>\n                    ,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). These correlative findings are consistent with the conclusion that cerebrovascular responsiveness to CO\n                    <jats:sub>2<\/jats:sub>\n                    is an important determinant of eupnoeic ventilation and of hypercapnic ventilatory responsiveness in humans, primarily via its effects at the level of the central chemoreceptors.\n                  <\/jats:p>","DOI":"10.1113\/jphysiol.2006.110627","type":"journal-article","created":{"date-parts":[[2006,8,24]],"date-time":"2006-08-24T20:27:36Z","timestamp":1156451256000},"page":"319-329","source":"Crossref","is-referenced-by-count":144,"title":["Influence of cerebrovascular function on the hypercapnic ventilatory response in healthy humans"],"prefix":"10.1113","volume":"577","author":[{"given":"Ailiang","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Skatrud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Chenuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Khayat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Reichmuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome A.","family":"Dempsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00285-004-0293-3"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1989.sp017578"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.5.913"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1047"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1969.tb04368.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1979.47.1.104"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1979.47.6.1289"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01617.2005"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1996.84.1.0079"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198912000-00015"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(87)90909-0"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00095-5"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1987.tb08054.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1983.tb07198.x"},{"key":"e_1_2_5_16_1","first-page":"115","volume-title":"Handbook of Physiology, section 3, The Respiratory System, vol II, Control of Breathing","author":"Fencl V","year":"1986"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1969.27.1.67"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199305000-00006"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198706000-00005"},{"key":"e_1_2_5_20_1","first-page":"641","article-title":"A pharmacological model of cerebral ischemia. 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